Solid-state structure, organization and properties of peptide - Synthetic hybrid block copolymers

被引:115
作者
Klok, Harm-Anton
Lecommandoux, Sebastien
机构
[1] Ecole Polytech Fed Lausanne, Inst Mat, Lab Polymeres, STI,IMX, CH-1015 Lausanne, Switzerland
[2] Univ Bordeaux 1, Lab Chim Polymeres Organ, UMR5629, CNRS,ENSCPB, F-33607 Pessac, France
来源
PEPTIDE HYBRID POLYMERS | 2006年 / 202卷
关键词
block copolymers; polypeptides; self-assembly;
D O I
10.1007/12_083
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Peptide-synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of a-amino acid N-carboxyanhydrides using appropriately end-functionalized synthetic polymers as the macroinitiator. This class of peptide-synthetic hybrid block copolymers has been the subject of longstanding scientific interest. First reports on the structure and properties of these hybrid block copolymers date from the 1970s. The advent of more refined analytical tools has spurred the interest in these materials and has led to an increased understanding of their structure and properties. This article presents an overview of the solid-state structure, organization and properties of the major classes of peptide-synthetic hybrid block copolymers, classified according to the chemical composition of the synthetic polymer block. For each of these classes of block copolymers, results from earlier morphological studies will be discussed and compared and complemented with more recent results. Properties and possible applications of peptide-synthetic hybrid block copolymers will also be pointed out.
引用
收藏
页码:75 / 111
页数:37
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