Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

被引：154
作者：
Chen, Min [1 ]
Du, Zhi-Yun [1 ]
Zheng, Xi [1 ,2 ,3 ,4 ]
Li, Dong-Li [3 ,4 ]
Zhou, Ren-Ping [2 ]
Zhang, Kun [1 ,3 ,4 ]
机构：
[1] Guangdong Univ Technol, Inst Nat Med Chem & Green Chem, Coll Light Ind & Chem Engn, Guangzhou, Guangdong, Peoples R China
[2] Rutgers State Univ, Susan Lehman Cullman Lab Canc Res, Dept Biol Chem, Ernest Mario Sch Pharm, Piscataway, NJ USA
[3] Wuyi Univ, Jiangmen, Guangdong, Peoples R China
[4] Int Healthcare Innovat Inst Jiangmen, Jiangmen, Guangdong, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2018年 / 13卷 / 04期
关键词：
nerve regeneration; curcumin; Alzheimer's disease; senile dementia; early diagnosis; positron emission tomography; magnetic resonance imaging; biological availability; chemical components; neurodegeneration; neural regeneration; AMYLOID-BETA; IN-VIVO; INFLAMMASOME ACTIVATION; CHEMOPREVENTIVE AGENT; CLINICAL-TRIAL; CROSS-LINKING; DOUBLE-BLIND; BRAIN; PLAQUES; MODEL;
D O I：
10.4103/1673-5374.230303
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-beta and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-beta. Because of its multi-target effects, curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease, hypertension, and hyper-lipidemia. For prevention and treatment of Alzheimer's disease, curcumin has been shown to effectively maintain the normal structure and function of cerebral vessels, mitochondria, and synapses, reduce risk factors for a variety of chronic diseases, and decrease the risk of Alzheimer's disease. The effect of curcumin on Alzheimer's disease involves multiple signaling pathways: anti-amyloid and metal iron chelating properties, antioxidation and anti-inflammatory activities. Indeed, there is a scientific basis for the rational application of curcumin in prevention and treatment of Alzheimer's disease.
引用
收藏
页码：742 / 752
页数：11
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