Imaging of nitroxides at 250 MHz using rapid-scan electron paramagnetic resonance

被引：28

作者：

Biller, Joshua R. ^{[1
,2
]}

Tseitlin, Mark ^{[1
,2
]}

Quine, Richard W. ^{[2
,3
]}

Rinard, George A. ^{[2
,3
]}

Weismiller, Hilary A. ^{[1
,2
]}

Elajaili, Hanan ^{[1
,2
]}

Rosen, Gerald M. ^{[4
,5
]}

Kao, Joseph P. Y. ^{[4
,6
]}

Eaton, Sandra S. ^{[1
,2
]}

Eaton, Gareth R. ^{[1
,2
]}

机构：

[1] Univ Denver, Dept Chem & Biochem, Denver, CO 80208 USA

[2] Univ Denver, Ctr EPR Imaging Vivo Physiol, Denver, CO 80208 USA

[3] Univ Denver, Sch Engn & Comp Sci, Denver, CO 80208 USA

[4] Univ Maryland, Sch Med, Ctr Biomed Engn & Technol, Baltimore, MD 21201 USA

[5] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[6] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2014年 / 242卷

关键词：

Nitroxide; Imaging; Rapid scan; 250 MHz EPR; RELAXATION-TIMES; CONTINUOUS-WAVE; EPR; PH;

D O I：

10.1016/j.jmr.2014.02.015

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Projections for 2D spectral-spatial images were obtained by continuous wave and rapid-scan electron paramagnetic resonance using a bimodal cross-loop resonator at 251 MHz. The phantom consisted of three 4 mm tubes containing different N-15,H-2-substituted nitroxides. Rapid-scan and continuous wave images were obtained with 5 min total acquisition times. For comparison, images also were obtained with 29 s acquisition time for rapid scan and 15 min for continuous wave. Relative to continuous wave projections obtained for the same data acquisition time, rapid-scan projections had significantly less low-frequency noise and substantially higher signal-to-noise at higher gradients. Because of the improved image quality for the same data acquisition, time, linewidths could be determined more accurately from the rapid-scan images than from the continuous wave images. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：162 / 168

页数：7

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