Synthesis, characterization, DNA interaction and cytotoxic activities of copper complexes with ethyl 2-[bis(2-pyridylmethyl)amino]propionate

被引：19

作者：

Chen, Qiu-Yun ^{[1
,2
]}

Huang, Juan ^{[1
,2
]}

Guo, Wen-Jie ^{[3
]}

Gao, Jing ^{[3
]}

机构：

[1] Jiangsu Univ, Inst Chem & Chem Engineer, Zhenjiang 212013, Peoples R China

[2] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 212093, Peoples R China

[3] Jiangsu Univ, Inst Med, Zhenjiang 212013, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2009年 / 72卷 / 03期

关键词：

DNA; Copper (II) complex; Spectroscopy; Cytotoxic activity; STRUCTURAL-CHARACTERIZATION; CRYSTAL-STRUCTURE; SCHIFF-BASE; LIGANDS; BINDING; THERMODYNAMICS; FLUORESCENCE; SERIES; AGENTS; OXYGEN;

D O I：

10.1016/j.saa.2008.11.006

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Copper(II) complexes of ethyl 2-[bis(2-pyridylmethyl)amino]propionate ligand (ETDPA) have been synthesized and characterized by elemental analyses, IR spectra, UV spectra and ES-MS. These complexes are stable in air with the formula of [(ETDPA)CuCl(2)] and [(ETDPA)Cu(phen)](ClO(4))(2). The DNA-binding properties of the Cu(II) complexes have been investigated by ultraviolet spectroscopy and fluorescence spectroscopy, which showed that the binding mode of the two complexes with DNA was different. The binding mode of [(ETDPA)CuCl(2)] is not the classical intercalation binding, and the binding mode of [(ETDPA)Cu(phen)](ClO(4))(2) with DNA is intercalation. The cytotoxic assay shows that the [(ETDPA)Cu(phen)](ClO(4))(2) is more active on the proliferation of cancer cells than the [(ETDPA)CuCl(2)]. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：648 / 653

页数：6

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