NASOPHARYNGEAL CARCINOMA IMMUNOTHERAPY: Current Strategies and Perspectives

被引：0
作者：
Smith, Corey [1 ]
Khanna, Rajiv [1 ]
机构：
[1] Queensland Inst Med Res, Div Infect Dis & Immunol, Tumour Immunol Lab, Australian Ctr Vaccine Dev, Brisbane, Qld 4006, Australia
来源：
NASOPHARYNGEAL CARCINOMA: KEYS FOR TRANSLATIONAL MEDICINE AND BIOLOGY | 2013年 / 778卷
关键词：
EPSTEIN-BARR-VIRUS; T-CELL EPITOPES; ANTIGEN-PROCESSING FUNCTION; MEMBRANE-PROTEIN; EBV-SPECIFIC CTL; ADOPTIVE IMMUNOTHERAPY; ENDOGENOUS PRESENTATION; RESPONSES; MEMORY; CD4(+);
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent success in treating Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disorder (PTLD) using cytotoxic T-cell (CTL) based immunotherapy has led to interest in the development of CTL-based immunotherapy to treat other EBV-associated malignancies, including Nasopharyngeal carcinoma (NPC). However unlike PTLD, which arises in immunosuppressed individuals following transplant, NPC can arise in immunocompetent individuals, expresses a limited array of EBV antigens that are poorly immunogenic, and appear to suppress the function of these T cells either directly or through the expansion of regulatory T cells. There is therefore a unique set of problems that need to be addressed in order to optimise CTL-therapy for the effective treatment of NPC.
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页码：173 / 186
页数：14
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