NASOPHARYNGEAL CARCINOMA IMMUNOTHERAPY: Current Strategies and Perspectives

被引：0

作者：

Smith, Corey ^{[1
]}

Khanna, Rajiv ^{[1
]}

机构：

[1] Queensland Inst Med Res, Div Infect Dis & Immunol, Tumour Immunol Lab, Australian Ctr Vaccine Dev, Brisbane, Qld 4006, Australia

来源：

NASOPHARYNGEAL CARCINOMA: KEYS FOR TRANSLATIONAL MEDICINE AND BIOLOGY | 2013年 / 778卷

关键词：

EPSTEIN-BARR-VIRUS; T-CELL EPITOPES; ANTIGEN-PROCESSING FUNCTION; MEMBRANE-PROTEIN; EBV-SPECIFIC CTL; ADOPTIVE IMMUNOTHERAPY; ENDOGENOUS PRESENTATION; RESPONSES; MEMORY; CD4(+);

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent success in treating Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disorder (PTLD) using cytotoxic T-cell (CTL) based immunotherapy has led to interest in the development of CTL-based immunotherapy to treat other EBV-associated malignancies, including Nasopharyngeal carcinoma (NPC). However unlike PTLD, which arises in immunosuppressed individuals following transplant, NPC can arise in immunocompetent individuals, expresses a limited array of EBV antigens that are poorly immunogenic, and appear to suppress the function of these T cells either directly or through the expansion of regulatory T cells. There is therefore a unique set of problems that need to be addressed in order to optimise CTL-therapy for the effective treatment of NPC.

引用

页码：173 / 186

页数：14

共 64 条

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