Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia

被引：9

作者：

Sanikidze, T. V. ^{[1
]}

Tkhilava, N. G.

Papava, M. B.

Datunashvili, I. V.

Gongadze, M. T.

Gamrekelashvili, D. D.

Bakhutashvili, V. I.

机构：

[1] Tbilisi State Med Univ, Inst Clin & Expt Med, Tbilisi, Georgia

[2] Georgian Acad Sci, Inst Expt & Clin Biotechnol, Tbilisi, Georgia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 02期

关键词：

nitric oxide; superoxide radical; oxidative stress; lipopolysaccharide; Plaferon LB;

D O I：

10.1007/s10517-006-0130-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxernia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress. Plaferon LB protected mice from the toxic effect of lipopolysaccharide.

引用

页码：211 / 215

页数：5

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