共 25 条
Simultaneous quantification of protein order and disorder
被引:101
作者:
Sormanni, Pietro
[1
]
Piovesan, Damiano
[2
,3
]
Heller, Gabriella T.
[1
]
Bonomi, Massimiliano
[1
]
Kukic, Predrag
[1
]
Camilloni, Carlo
[4
,5
]
Fuxreiter, Monika
[6
]
Dosztanyi, Zsuzsanna
[7
]
Pappu, Rohit V.
[8
,9
]
Babu, M. Madan
[10
]
Longhi, Sonia
[11
]
Tompa, Peter
[12
,13
]
Dunker, A. Keith
[14
,15
]
Uversky, Vladimir N.
[16
,17
]
Tosatto, Silvio C. E.
[2
,3
]
Vendruscolo, Michele
[1
]
机构:
[1] Univ Cambridge, Dept Chem, Cambridge, England
[2] Univ Padua, Dept Biomed Sci, Padua, Italy
[3] Univ Padua, CRIBI Biotechnol Ctr, Padua, Italy
[4] Tech Univ Munich, Dept Chem, Garching, Germany
[5] Tech Univ Munich, Inst Adv Study, Garching, Germany
[6] Univ Debrecen, Dept Biochem & Mol Biol, MTA Momentum Lab Prot Dynam, Debrecen, Hungary
[7] Eotvos Lorand Univ, MTA ELTE Lendulet Bioinformat Res Grp, Dept Biochem, Budapest, Hungary
[8] Washington Univ, Dept Biomed Engn, St Louis, MO USA
[9] Washington Univ, Ctr Biol Syst Engn, St Louis, MO USA
[10] MRC Lab Mol Biol, Cambridge, England
[11] Aix Marseille Univ, AFMB, CNRS, Marseille, France
[12] Vrije Univ Brussel, VIB Ctr Struct Biol, Brussels, Belgium
[13] Inst Enzymol, Budapest, Hungary
[14] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Ctr Computat Biol & Bioinformat, Indianapolis, IN USA
[15] Indiana Univ, Sch Informat, Dept Biochem & Mol Biol, Ctr Computat Biol & Bioinformat, Indianapolis, IN USA
[16] Univ S Florida, Morsani Coll Med, Dept Mol Biol, Tampa, FL USA
[17] Univ S Florida, Morsani Coll Med, USF Hlth Byrd Alzheimers Res Inst, Tampa, FL USA
关键词:
STRUCTURAL BIOLOGY;
ATOMIC-RESOLUTION;
CHEMICAL-SHIFTS;
NMR;
STATES;
POPULATIONS;
DYNAMICS;
REGIONS;
D O I:
10.1038/nchembio.2331
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Nuclear magnetic resonance spectroscopy is transforming our views of proteins by revealing how their structures and dynamics are closely intertwined to underlie their functions and interactions. Compelling representations of proteins as statistical ensembles are uncovering the presence and biological relevance of conformationally heterogeneous states, thus gradually making it possible to go beyond the dichotomy between order and disorder through more quantitative descriptions that span the continuum between them.
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页码:339 / 342
页数:4
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