Standardized decision support in next generation sequencing reports of somatic cancer variants

被引:67
作者
Dienstmann, Rodrigo [1 ,2 ]
Dong, Fei [1 ,2 ]
Borger, Darrell [3 ,4 ]
Dias-Santagata, Dora [1 ,2 ]
Ellisen, Leif W. [3 ,4 ]
Le, Long P. [1 ,2 ]
Iafrate, A. John [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Mol Pathol Lab, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
[4] Harvard Univ, Sch Med, Boston, MA 02114 USA
关键词
Cancer; Genomics; Next-generation sequencing; Report; Variant annotation; PLECKSTRIN HOMOLOGY DOMAIN; CELL LUNG-CANCER; LOSS-OF-FUNCTION; MUTATIONS; TUMORS; SENSITIVITY; RESISTANCE; INHIBITION; PONATINIB; MELANOMA;
D O I
10.1016/j.molonc.2014.03.021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Of hundreds to thousands of somatic mutations that exist in each cancer genome, a large number are unique and non-recurrent variants. Prioritizing genetic variants identified via next generation sequencing technologies remains a major challenge. Many such variants occur in tumor genes that have well-established biological and clinical relevance and are putative targets of molecular therapy, however, most variants are still of unknown significance. With large amounts of data being generated as high throughput sequencing assays enter the clinical realm, there is a growing need to better communicate relevant findings in a timely manner while remaining cognizant of the potential consequences of misuse or overinterpretation of genomic information. Herein we describe a systematic framework for variant annotation and prioritization, and we propose a structured molecular pathology report using standardized terminology in order to best inform oncology clinical practice. We hope that our experience developing a comprehensive knowledge database of emerging predictive markers matched to targeted therapies will help other institutions implement similar programs. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:859 / 873
页数:15
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