Relevance of genetic investigation in male infertility

被引：41

作者：

Asero, P. ^{[1
]}

Calogero, A. E. ^{[1
]}

Condorelli, R. A. ^{[1
]}

Mongioi', L. ^{[1
]}

Vicari, E. ^{[1
]}

Lanzafame, F. ^{[1
]}

Crisci, R. ^{[1
]}

La Vignera, S. ^{[1
]}

机构：

[1] Univ Catania, Policlin G Rodol, Dipartimento Sci Med & Pediat, Sez Endocrinol Androl & Med Interna, I-95123 Catania, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2014年 / 37卷 / 05期

关键词：

Male infertility; Genetic causes; Chromosomal alterations; HUMAN Y-CHROMOSOME; ANDROGEN RECEPTOR GENE; INTRACYTOPLASMIC SPERM INJECTION; CONGENITAL BILATERAL ABSENCE; AZF-CANDIDATE GENES; N-TERMINAL DOMAIN; MITOCHONDRIAL-DNA; VAS-DEFERENS; CYSTIC-FIBROSIS; SEMEN QUALITY;

D O I：

10.1007/s40618-014-0053-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic causes can be directly responsible for various clinical conditions of male infertility and spermatogenic impairment. With the increased use of assisted reproduction technologies our understanding of genetic basis of male infertility has large implications not only for understanding the causes of infertility but also in determining the prognosis and management of such couples. For these reasons, the genetic investigations represent today an essential and useful tool in the treatment of male infertility. Several evidences are available for the clinical practice regarding the diagnosis; however, there are less information relative to the treatment of the genetic causes of male infertility. Focus of this review is to discuss the main and more common genetic causes of male infertility to better direct the genetics investigation in the treatment of spermatogenic impairment.

引用

页码：415 / 427

页数：13

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