Severe Sepsis-Associated Morbidity and Mortality among Critically Ill Children with Cancer

被引：22

作者：

Aljabari, Salim ^{[1
]}

Balch, Alfred ^{[2
]}

Larsen, Gitte Y. ^{[1
]}

Fluchel, Mark ^{[3
]}

Workman, Jennifer K. ^{[1
]}

机构：

[1] Univ Utah, Dept Pediat, Div Pediat Crit Care, 295 Chipeta Way,POB 581289, Salt Lake City, UT 84108 USA

[2] Univ Utah, Dept Pediat, Div Clin Pharmacol, Salt Lake City, UT 84108 USA

[3] Univ Utah, Dept Pediat, Div Pediat Hematol & Oncol, Salt Lake City, UT 84108 USA

来源：

JOURNAL OF PEDIATRIC INTENSIVE CARE | 2019年 / 8卷 / 03期

关键词：

sepsis; septic shock; oncology; morbidity and mortality; INTENSIVE-CARE-UNIT; PEDIATRIC SEVERE SEPSIS; ORGAN DYSFUNCTION SYNDROME; ONCOLOGY PATIENTS; CLINICAL-COURSE; RISK; FEVER; EPIDEMIOLOGY; MALIGNANCIES; INFECTION;

D O I：

10.1055/s-0038-1676658

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Severe sepsis (SS) in pediatric oncology patients is a leading cause of morbidity and mortality. We investigated the incidence of and risk factors for morbidity and mortality among children diagnosed with cancer from 2008 to 2012, and admitted with SS during the 3 years following cancer diagnosis. A total of 1,002 children with cancer were included, 8% of whom required pediatric intensive care unit (PICU) admission with SS. Death and/or multiple organ dysfunction syndrome occurred in 34 out of 99 PICU encounters (34%). Lactate level and history of stem-cell transplantation were significantly associated with the development of death and/or organ dysfunction (p < 0.05).

引用

页码：122 / 129

页数：8

共 35 条

[1] Bloodstream infection in paediatric cancer centres-leukaemia and relapsed malignancies are independent risk factors [J].