The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

被引：69

作者：

Haack, Timm ^{[1
]}

Abdelilah-Seyfried, Salim ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Inst Mol Biol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] Univ Potsdam, Inst Biochem & Biol, Karl Liebknecht Str 24-25, D-14476 Potsdam, Germany

来源：

DEVELOPMENT | 2016年 / 143卷 / 03期

关键词：

Endocardium; Cardiac development; Hemodynamics; Bmp; Kruppel-like factor 2; Vegf; Mechanotransduction; Zebrafish; Mouse; FLUID SHEAR-STRESS; 2ND HEART FIELD; TO-MESENCHYMAL TRANSITION; ZEBRAFISH HEART; TRANSCRIPTION FACTOR; BLOOD-FLOW; MYOCARDIAL MIGRATION; VASCULAR DEVELOPMENT; ENDOTHELIAL-CELLS; PROGENITOR CELLS;

D O I：

10.1242/dev.131425

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.

引用

页码：373 / 386

页数：14

共 192 条

[111]

Mickoleit M, 2014, NAT METHODS, V11, P919, DOI [10.1038/NMETH.3037, 10.1038/nmeth.3037]

[112] Congenital heart malformations induced by hemodynarnic altering surgical interventions [J].

Midgettand, Madeline ;

Rugonyi, Sandra .

FRONTIERS IN PHYSIOLOGY, 2014, 5

[113] Development of the cardiac conduction system [J].

Mikawa, Takashi ;

Hurtado, Romulo .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2007, 18 (01) :90-100

[114] The heart endocardium is derived from vascular endothelial progenitors [J].

Milgrom-Hoffman, Michal ;

Harrelson, Zachary ;

Ferrara, Napoleone ;

Zelzer, Elazar ;

Evans, Sylvia M. ;

Tzahor, Eldad .

DEVELOPMENT, 2011, 138 (21) :4777-4787

[115] Endocardial cells are a distinct endothelial lineage derived from Flk1+multipotent cardiovascular progenitors [J].

Misfeldt, Andrew M. ;

Boyle, Scott C. ;

Tompkins, Kevin L. ;

Bautch, Victoria L. ;

Labosky, Patricia A. ;

Baldwin, H. Scott .

DEVELOPMENTAL BIOLOGY, 2009, 333 (01) :78-89

[116] Effect of Vascular Cadherin Knockdown on Zebrafish Vasculature during Development [J].

Mitchell, Ian C. ;

Brown, Timothy S. ;

Terada, Lance S. ;

Amatruda, James F. ;

Nwariaku, Fiemu E. .

PLOS ONE, 2010, 5 (01)

[117] Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143 [J].

Miyasaka, Kota Y. ;

Kida, Yasuyuki S. ;

Banjo, Toshihiro ;

Ueki, Yosuke ;

Nagayama, Kazuaki ;

Matsumoto, Takeo ;

Sato, Masaaki ;

Ogura, Toshihiko .

MECHANISMS OF DEVELOPMENT, 2011, 128 (1-2) :18-28

[118] Cardiac chamber formation: Development, genes, and evolution [J].

Moorman, AFM ;

Christoffels, VM .

PHYSIOLOGICAL REVIEWS, 2003, 83 (04) :1223-1267

[119] Multipotent embryonic Isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification [J].

Moretti, Alessandra ;

Caron, Leslie ;

Nakano, Atsushi ;

Lam, Jason T. ;

Bernshausen, Alexandra ;

Chen, Yinhong ;

Qyang, Yibing ;

Bu, Lei ;

Sasaki, Mika ;

Martin-Puig, Silvia ;

Sun, Yunfu ;

Evans, Sylvia M. ;

Laugwitz, Karl-Ludwig ;

Chien, Kenneth R. .

CELL, 2006, 127 (06) :1151-1165

[120] Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development [J].

Morris, JK ;

Lin, WC ;

Hauser, C ;

Marchuk, Y ;

Getman, D ;

Lee, KF .

NEURON, 1999, 23 (02) :273-283

← 7 8 9 10 11 12 13 14 15 16 →