Can a brief psychological expectancy intervention improve postoperative pain? A randomized, controlled trial in patients with breast cancer

被引:27
作者
Benson, Sven [1 ]
Hagen, Susanne [2 ]
Hoffmann, Oliver [3 ]
Pasler, Annika [1 ,2 ]
Bingel, Ulrike [4 ]
Schedlowski, Manfred [1 ]
Peters, Juergen [2 ]
Elsenbruch, Sigrid [1 ]
Frey, Ulrich H. [2 ,5 ]
机构
[1] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Psychol & Behav Immunobiol, Essen, Germany
[2] Univ Duisburg Essen, Univ Hosp Essen, Klin Anasthesiol & Intens Med, Essen, Germany
[3] Univ Duisburg Essen, Univ Hosp Essen, Clin Obstet & Gynecol, Essen, Germany
[4] Univ Duisburg Essen, Univ Hosp Essen, Clin Neurol, Essen, Germany
[5] Ruhr Univ Bochum, Marienhosp Herne, Dept Anesthesiol, Bochum, Germany
关键词
Postoperative pain; Placebo analgesia; Psychological intervention; Positive expectations; Sham acupuncture; Patient-controlled intravenous analgesia; PLACEBO ANALGESIA; RISK-FACTORS; POSTSURGICAL PAIN; NOCEBO RESPONSES; PERSISTENT PAIN; SURGERY; EXPECTATIONS; ACUPUNCTURE; MECHANISMS; RELIEF;
D O I
10.1097/j.pain.0000000000001546
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Pain after surgery remains a major health problem, calling for optimized treatment regimens to maximize the efficacy of pharmacological interventions. In this randomized controlled trial, we tested in a routine surgical treatment setting whether postoperative pain can be reduced by a brief preoperative intervention, ie, positive verbal suggestions in combination with sham acupuncture, designed to optimize treatment expectations. We hypothesized that the expectancy intervention as add-on to patient-controlled intravenous analgesia with morphine reduces patient-reported postoperative pain and improves satisfaction with analgesia. Ninety-six women undergoing breast cancer surgery were randomized at 2 stages: Before surgery, anesthesiologists delivered either positive or neutral verbal suggestions regarding the benefits of acupuncture needling on postoperative pain ("information condition"). Patients were then randomized to receive sham acupuncture or no sham acupuncture during postoperative care ("sham acupuncture condition"). Average pain during the 24-hour observation period after surgery as primary and satisfaction with analgesia as secondary outcome was assessed with standardized measures and analyzed with analysis of covariance accounting for morphine dose, surgery-related, and psychological parameters. Postoperative pain ratings were significantly reduced in patients who received positive treatment-related suggestions (F = 4.45, P = 0.038, main effect of information). Moreover, patients who received an intervention aimed at optimized treatment expectations reported significantly greater satisfaction with analgesia (F = 4.89, P = 0.030, interaction effect). Together, our proof-of-concept data support that optimizing treatment expectations through verbal suggestions may offer a promising approach to improve patient-reported outcomes. Future translational and clinical studies are needed to test such psychological strategies in different surgical interventions, patient groups, and pharmacological treatment regimens.
引用
收藏
页码:1562 / 1571
页数:10
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