Enhancement of Lanthanum (III) on Sodium Currents in Acutely Isolated Hippocampal CA1 Neurons of Rat

被引：2

作者：

Du, Huizhi ^{[1
]}

Yang, Pin ^{[1
]}

机构：

[1] Shanxi Univ, Inst Mol Sci, Minist Educ, Key Lab Chem Biol & Mol Engn, Taiyuan 030006, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2009年 / 34卷 / 09期

关键词：

Lanthanum (III); Sodium current; Hippocampal CA1 neurons; The whole-cell patch clamp techniques; MYELINATED NERVE-FIBERS; SURFACE-CHARGE; CALCIUM; PROLIFERATION; CONTRIBUTES; DIVALENT; CHANNELS; LA3+; K+;

D O I：

10.1007/s11064-009-9944-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of lanthanum (III) (La3+) on voltage-gated sodium channel currents (I (Na)) in freshly dissociated rat hippocampal CA1 neurons were studied using the whole-cell patch clamp techniques. La3+ reversibly enhanced I (Na) in a concentration- and voltage-dependent manner. The 50% enhancement concentration (EC50) of La3+ on I (Na) was 9.93 mu M. In addition, 10 mu M La3+ shifted the steady state activation curve of I (Na) towards positive potential and the steady state inactivation curve towards negative potential without changing the slope factor. These results indicated that La3+ could increase the amplitudes of I (Na) and change the activation and inactivation courses of I (Na) even in very low concentration.

引用

页码：1562 / 1567

页数：6

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