Distribution of β-lactamases in Acinetobacter baumannii clinical isolates and the effect of Syn 2190 (AmpC inhibitor) on the MICs of different β-lactam antibiotics

被引：27

作者：

Danes, C ^{[1
]}

Navia, MM ^{[1
]}

Ruiz, J ^{[1
]}

Marco, F ^{[1
]}

Jurado, A ^{[1
]}

de Anta, MTJ ^{[1
]}

Vila, J ^{[1
]}

机构：

[1] Univ Barcelona, Microbiol Serv, Inst Clin Infecc & Immunol, Hosp Clin IDIBAPS, E-08036 Barcelona, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 50卷 / 02期

关键词：

D O I：

10.1093/jac/dkf092

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The distribution of beta-lactamases in a group of 20 epidemiologically well defined Acinetobacter baumannii clinical isolates and the in vitro activity of Syn 2190, a novel beta-lactamase AmpC inhibitor, were determined. Twenty-five per cent of the strains carried and expressed a TEM-type beta-lactamase, whereas 35% had an OXA-type beta-lactamase. In nine out of 11 (82%) ceftazidime-resistant and four out of 13 (30.7%) cefepime-resistant strains, the MIC of these beta-lactam antibiotics decreased when determined in the presence of Syn 2190. Thus, our results suggest that in a high percentage of A. baumannii clinical isolates the increased production of AmpC, in combination or not with other resistance mechanisms, contributes to the resistance pattern in A. baumannii to beta-lactams.

引用

页码：261 / 264

页数：4

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