HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and poor prognosis in a Chinese population

被引：47
|
作者：
Qiu, Haifeng [1 ,2 ]
Wang, Xiujuan [1 ,2 ]
Guo, Ruixia [1 ,2 ]
Liu, Qiuli [3 ,4 ]
Wang, Yuan [3 ,4 ]
Yuan, Zhongfu [1 ,2 ]
Li, Jing [5 ]
Shi, Huirong [1 ,2 ]
机构：
[1] Zhengzhou Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China
[2] Zhengzhou Univ, Ovarian & Cerv Dis Clin Treatment Ctr Henan Prov, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China
[3] Jiangnan Univ, Dept Obstet & Gynecol, Affiliated Hosp, Wuxi 214062, Peoples R China
[4] Fourths Peoples Hosp Wuxi, Wuxi 214062, Peoples R China
[5] Zhengzhou Univ, Dept Oncol, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 04期
关键词：
cancer susceptibility; HOTAIR; long noncoding RNA; ovarian cancer; prognosis; rs920778; polymorphism; LONG NONCODING RNA; EXPRESSION; INVASION; METASTASIS; REVERSES;
D O I：
10.2217/fon-2016-0290
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: The aim of this study was to determine if HOTAIR rs920778 polymorphism is associated with ovarian cancer susceptibility and prognosis. Materials & methods: The data were obtained from two independent groups including 329 ovarian cancer patients and 680 cancer-free, age-matched women. Blood samples were collected and genomic DNA was extracted for genotyping. Results: TT genotype and T allele of HOTAIR rs920778 were significantly associated with a decreased ovarian cancer risk (p = 0.0004 and p < 0.0001, respectively), which associated with advanced tumor stage, lymph node metastasis and poor prognosis. Moreover, TT and TC carriers obtained a much shorter survival (p = 0.026). Conclusion: These findings propose that HOTAIR rs920778 polymorphism influences ovarian cancer susceptibility and prognosis, and further studies are warranted in other populations.
引用
收藏
页码：347 / 355
页数：9
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