Interferon-γ-independent CD8+ T cell-mediated protective anti-malaria immunity elicited by recombinant adenovirus

被引：0
|
作者：
Rodrigues, EG
Claassen, J
Lee, S
Wilson, JM
Nussenzweig, RS
Tsuji, M [1 ]
机构：
[1] NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA
[2] Univ Penn, Dept Mol & Cellular Engn, Inst Human Gene Therapy, Philadelphia, PA 19104 USA
来源：
PARASITE IMMUNOLOGY | 2000年 / 22卷 / 03期
关键词：
liver stages; Plasmodium yoelii; recombinant adenovirus; IFN-gamma; CD8(+) T cells; protection;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recombinant adenovirus, expressing the CS protein of Plasmodium yoelii, AdPyCS, was shown to induce a comparable degree of T cell-mediated protection against malaria as a single dose of irradiated P. yoelii sporozoites, causing inhibition of liver stage development. We now report that differently from sporozoite-induced immunity, interferon (IFN)-gamma does not mediate the protective immunity induced by AdPyCS, since a similar degree of protection was observed in AdPyCS immunized mice lacking IFN-gamma(-/-) and the IFN-gamma receptor (IFN-gamma R-/-) compared to that in wild-type mice. Depletion of CD8(+) T cells from these immunized mice almost completely abolished the AdPyCS-induced immunity, indicating that the immunization with AdPyCS induces CD8(+) T cell-mediated protective anti-malaria immunity, which is independent of IFN-gamma.
引用
收藏
页码：157 / 160
页数：4
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