Stem cell therapy for osteonecrosis of femoral head: Opportunities and challenges

被引:63
作者
Xu, Yingxing [1 ,3 ,4 ]
Jiang, Yaping [2 ,3 ]
Xia, ChangSuo [1 ]
Wang, Yingzhen [1 ]
Zhao, Zhiping [1 ,3 ,4 ]
Li, Tao [1 ]
机构
[1] Qingdao Univ, Dept Joint Surg, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China
[2] Qingdao Univ, Dept Stomatol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China
[3] Qingdao Univ, Qingdao 266071, Shandong, Peoples R China
[4] Qingdao Univ, Med Dept, Qingdao 266071, Shandong, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
Osteonecrosis; Femoral head; Cell therapy; Cell implantation; Stem cells; Tissue engineering; TOTAL HIP-ARTHROPLASTY; STEROID-INDUCED OSTEONECROSIS; GLUCOCORTICOID-INDUCED OSTEONECROSIS; EARLY-STAGE OSTEONECROSIS; MARROW MONONUCLEAR-CELLS; FIBROBLAST-GROWTH-FACTOR; BONE-MARROW; AVASCULAR NECROSIS; CORE DECOMPRESSION; MORPHOGENETIC PROTEIN-2;
D O I
10.1016/j.reth.2020.11.003
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Osteonecrosis of the femoral head (ONFH) is a progressive disease with a complex etiology and unclear pathogenesis, resulting in severe hip pain and dysfunction mainly observed in young patients. Although total hip arthroplasty (THA) is the most effective treatment for patients with ONFH in the terminal stage, the results of THA in young patients or active populations are often not favorable, with some complications related to the prosthesis. With the development of biotechnology, an increasing number of studies pay attention to use of stem cells for the treatment of ONFH. Stem cells are characterized by the ability to self-renew and differentiate into multiple cell types, including differentiation into osteoblasts and endothelial cells to mediate bone repair and angiogenesis. Furthermore, stem cells can offer growth factors to promote blood supply in the necrotic regions by paracrine effects. Therefore, stem cell therapy has become one of the hip-preserving alternatives for ONFH. This review summarized the current trends in stem cell therapy for ONFH, from clinical applications to related basic research, and showed that an increasing number of studies have confirmed the effectiveness of stem cell therapy in ONFH. However, many unsolved problems and challenges in practical applications of stem cell therapy still exist, such as patient selection, standardized procedures, safety assessment, and the fate of transplanted cells in the body. Additional studies are required to find ideal cell sources, appropriate transplantation methods, and the optimal number of cells for transplantation. (C) 2020, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
引用
收藏
页码:295 / 304
页数:10
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