How Low Cholesterol Is Good for Anti-viral Immunity

被引：23
作者：
O'Neill, Luke A. J. [1 ]
机构：
[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin 2, Ireland
来源：
CELL | 2015年 / 163卷 / 07期
关键词：
D O I：
10.1016/j.cell.2015.12.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
York et al. identify a role for decreased cholesterol biosynthesis in virally infected cells as a critical event in the induction of the anti-viral response. The mechanism involves enhanced signaling by STING in the ER membrane in response to the second messenger cGAMP, promoting increased transcription of type I interferons. The authors suggest that a "lipid code" is being sensed by STING to allow it to signal.
引用
收藏
页码：1572 / 1574
页数：4
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