Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol

被引：64
|
作者：
Basaraba, Randall J. [1 ]
Smith, Erin E. [1 ]
Shanley, Crystal A. [1 ]
Orme, Ian M. [1 ]
机构：
[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA
来源：
INFECTION AND IMMUNITY | 2006年 / 74卷 / 09期
关键词：
EXPERIMENTAL AIRBORNE TUBERCULOSIS; CELL; LUNG; VACCINATION; NECROSIS;
D O I：
10.1128/IAI.00332-06
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.
引用
收藏
页码：5397 / 5401
页数：5
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