Controllable Peptide-Dendron Self-Assembly: Interconversion of Nanotubes and Fibrillar Nanostructures

被引：95
作者：
Shao, Hui [1 ]
Parquette, Jon R. [1 ]
机构：
[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 14期
基金：
美国国家科学基金会;
关键词：
dendrons; nanofibrils; nanotubes; peptides; self-assembly; ORGANIC NANOTUBES; THIOFLAVIN-T; CONFORMATION; ORGANIZATION; AGGREGATION; RESIDUES; BINDING; MODEL;
D O I：
10.1002/anie.200805010
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Roll up: A peptide-dendron hybrid (PDH) is capable of selfassembling into either a soluble nanotube or an amyloidlike fibrillar network. The structures interconvert on adjusting the salt concentration or pH value. Their hydrophobic interfaces efficiently encapsulate hydrophobic molecules in water which can then be released by lowering the pH value. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2525 / 2528
页数：4
相关论文
共 57 条
[1]   Hierarchical self-assembly of chiral rod-like molecules as a model for peptide β-sheet tapes, ribbons, fibrils, and fibers [J].
Aggeli, A ;
Nyrkova, IA ;
Bell, M ;
Harding, R ;
Carrick, L ;
McLeish, TCB ;
Semenov, AN ;
Boden, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :11857-11862
[2]  
[Anonymous], 1980, The Mechanical Properties of Biological Materials
[3]   Self assembly of biologically inspired amphiphiles [J].
Berti, Debora .
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2006, 11 (01) :74-78
[4]   C-terminal PEG blocks the irreversible step in β-amyloid(10-35) fibrillogenesis [J].
Burkoth, TS ;
Benzinger, TLS ;
Jones, DNM ;
Hallenga, K ;
Meredith, SC ;
Lynn, DG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (30) :7655-7656
[5]  
Cherny I., 2008, Angew. Chem, V120, P4128
[6]   Amyloids: Not only pathological agents but also ordered nanomaterials [J].
Cherny, Izhack ;
Gazit, Ehud .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (22) :4062-4069
[7]   Self-assembly of multidomain peptides: Balancing molecular frustration controls conformation and nanostructure [J].
Dong, He ;
Paramonov, Sergey E. ;
Aulisa, Lorenzo ;
Bakota, Erica L. ;
Hartgerink, Jeffrey D. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (41) :12468-12472
[8]   AFM study of glucagon fibrillation via oligomeric structures resulting in interwoven fibrils [J].
Dong, Mingdong ;
Hovgaard, Mads Bruun ;
Xu, Sailong ;
Otzen, Daniel Erik ;
Besenbacher, Flemming .
NANOTECHNOLOGY, 2006, 17 (16) :4003-4009
[9]   The structure of a mycobacterial outer-membrane channel [J].
Faller, M ;
Niederweis, M ;
Schulz, GE .
SCIENCE, 2004, 303 (5661) :1189-1192
[10]   A possible role for π-stacking in the self-assembly of amyloid fibrils [J].
Gazit, E .
FASEB JOURNAL, 2002, 16 (01) :77-83
123456