An animal-to-human scaling law for blast-induced traumatic brain injury risk assessment

被引:55
作者
Jean, Aurelie [1 ,2 ]
Nyein, Michelle K. [1 ,2 ]
Zheng, James Q. [4 ]
Moore, David F. [1 ]
Joannopoulos, John D. [1 ,3 ]
Radovitzky, Raul [1 ,2 ]
机构
[1] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA
[2] MIT, Dept Aeronaut & Astronaut, Cambridge, MA 02139 USA
[3] MIT, Dept Phys, Cambridge, MA 02139 USA
[4] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA
关键词
interspecies scaling; injury risk criteria; transfer function; TBI; VIRTUAL TEST FACILITY; DYNAMIC-RESPONSE; HEAD; BIOMECHANICS; SIMULATION; MODEL; EXPOSURE; SHOCK; RATS; IRAQ;
D O I
10.1073/pnas.1415743111
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Despite recent efforts to understand blast effects on the human brain, there are still no widely accepted injury criteria for humans. Recent animal studies have resulted in important advances in the understanding of brain injury due to intense dynamic loads. However, the applicability of animal brain injury results to humans remains uncertain. Here, we use advanced computational models to derive a scaling law relating blast wave intensity to the mechanical response of brain tissue across species. Detailed simulations of blast effects on the brain are conducted for different mammals using image-based biofidelic models. The intensity of the stress waves computed for different external blast conditions is compared across species. It is found that mass scaling, which successfully estimates blast tolerance of the thorax, fails to capture the brain mechanical response to blast across mammals. Instead, we show that an appropriate scaling variable must account for the mass of protective tissues relative to the brain, as well as their acoustic impedance. Peak stresses transmitted to the brain tissue by the blast are then shown to be a power function of the scaling parameter for a range of blast conditions relevant to TBI. In particular, it is found that human brain vulnerability to blast is higher than for any other mammalian species, which is in distinct contrast to previously proposed scaling laws based on body or brain mass. An application of the scaling law to recent experiments on rabbits furnishes the first physics-based injury estimate for blast-induced TBI in humans.
引用
收藏
页码:15310 / 15315
页数:6
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