Topographical and Temporal Diversity of the Human Skin Microbiome

被引：2152

作者：

Grice, Elizabeth A. ^{[1
]}

Kong, Heidi H. ^{[2
]}

Conlan, Sean ^{[1
]}

Deming, Clayton B. ^{[1
]}

Davis, Joie ^{[3
]}

Young, Alice C. ^{[4
]}

Bouffard, Gerard G. ^{[4
,5
]}

Blakesley, Robert W. ^{[4
,5
]}

Murray, Patrick R. ^{[6
]}

Green, Eric D. ^{[4
,5
]}

Turner, Maria L. ^{[2
]}

Segre, Julia A. ^{[1
]}

机构：

[1] NHGRI, Genet & Mol Biol Branch, Bethesda, MD 20892 USA

[2] NCI, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[3] NHGRI, Off Translat Res, Bethesda, MD 20892 USA

[4] NHGRI, NIH, Intramural Sequencing Ctr, Bethesda, MD 20892 USA

[5] NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA

[6] NIH, Clin Microbiol Lab, Dept Lab Med, Ctr Clin, Bethesda, MD 20892 USA

来源：

SCIENCE | 2009年 / 324卷 / 5931期

关键词：

BACTERIAL BIOTA;

D O I：

10.1126/science.1171700

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. Our analysis of 16S ribosomal RNA gene sequences obtained from 20 distinct skin sites of healthy humans revealed that physiologically comparable sites harbor similar bacterial communities. The complexity and stability of the microbial community are dependent on the specific characteristics of the skin site. This topographical and temporal survey provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin.

引用

页码：1190 / 1192

页数：3

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