Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease

被引：69
作者：
Bodor, N
Buchwald, P
机构：
[1] IVAX Res, Miami, FL 33137 USA
[2] Univ Florida, Ctr Drug Discovery, Gainesville, FL 32610 USA
来源：
DRUG DISCOVERY TODAY | 2002年 / 7卷 / 14期
关键词：
D O I：
10.1016/S1359-6446(02)02332-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Brain-targeted chemical delivery systems (CDSs) represent rational drug design attempts not only to deliver but also to target drugs to their site of action. Using a sequential metabolism approach, the special bidirectional properties of the blood-brain barrier can be exploited to smuggle the precursors of therapeutic compounds across the barrier and lock them inside the brain ready for sustained release of the active drugs. Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail.
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收藏
页码：766 / 774
页数：9
相关论文
共 73 条
[1]   EVIDENCE FOR THE REESTABLISHMENT OF COPULATORY-BEHAVIOR IN CASTRATED MALE-RATS WITH A BRAIN-ENHANCED ESTRADIOL-CHEMICAL DELIVERY SYSTEM [J].
ANDERSON, WR ;
SIMPKINS, JW ;
BREWSTER, ME ;
BODOR, N .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 27 (02) :265-271
[2]   Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study [J].
Asthana, S ;
Craft, S ;
Baker, LD ;
Raskind, MA ;
Birnbaum, RS ;
Lofgreen, CP ;
Veith, RC ;
Plymate, SR .
PSYCHONEUROENDOCRINOLOGY, 1999, 24 (06) :657-677
[3]   High-dose estradiol improves cognition for women with AD - Results of a randomized study [J].
Asthana, S ;
Baker, LD ;
Craft, S ;
Stanczyk, FZ ;
Veith, RC ;
Raskind, MA ;
Plymate, SR .
NEUROLOGY, 2001, 57 (04) :605-612
[4]   The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system [J].
Begley, DJ .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1996, 48 (02) :136-146
[5]   Neuroprotective activities of estrogen: An update [J].
Behl, C ;
Manthey, D .
JOURNAL OF NEUROCYTOLOGY, 2000, 29 (5-6) :351-358
[6]   Thyroid hormone negatively regulates the transcriptional activity of the β-amyloid precursor protein gene [J].
Belandia, B ;
Latasa, MJ ;
Villa, A ;
Pascual, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) :30366-30371
[7]   Effect of neuropeptides on cognitive function [J].
Bennett, GW ;
Ballard, TM ;
Watson, CD ;
Fone, KCF .
EXPERIMENTAL GERONTOLOGY, 1997, 32 (4-5) :451-469
[8]  
Beral V, 1999, J Epidemiol Biostat, V4, P191
[9]   PROBLEMS OF DELIVERY OF DRUGS TO THE BRAIN [J].
BODOR, N ;
BREWSTER, ME .
PHARMACOLOGY & THERAPEUTICS, 1982, 19 (03) :337-386
[10]  
Bodor N, 1998, CHEM BRIT, V34, P36
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