Molecular and cellular basis of scleroderma

被引：40

作者：

Eckes, Beate ^{[1
]}

Moinzadeh, Pia ^{[1
]}

Sengle, Gerhard ^{[2
,3
]}

Hunzelmann, Nico ^{[1
]}

Krieg, Thomas ^{[1
,3
,4
]}

机构：

[1] Univ Cologne, Dept Dermatol, D-50937 Cologne, Germany

[2] Univ Cologne, Ctr Biochem, D-50937 Cologne, Germany

[3] Univ Cologne, CMMC, D-50937 Cologne, Germany

[4] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50937 Cologne, Germany

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2014年 / 92卷 / 09期

关键词：

Systemic sclerosis; Scleroderma; Extracellular microenvironment; Pathophysiology; Signaling; CUTANEOUS SYSTEMIC-SCLEROSIS; GENOME-WIDE ASSOCIATION; GROWTH-FACTOR RECEPTOR; CONNECTIVE-TISSUE; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; STIMULATORY AUTOANTIBODIES; DISEASE SCLERODERMA; STRUCTURAL-ANALYSIS; COLLAGEN-SYNTHESIS;

D O I：

10.1007/s00109-014-1190-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Systemic sclerosis (scleroderma) is a chronic inflammatory disease that leads to fibrosis of the skin and involved internal organs. No efficient therapy is currently available. This review summarizes recent progress made in basic as well as clinical science and concludes with a concept that therapy targeting fibrosis in scleroderma needs to take into account the global microenvironment in the skin with its diverse cellular players interacting with a complex extracellular matrix environment and matrix-associated growth factors.

引用

页码：913 / 924

页数：12

共 130 条

[1] Connective tissue growth factor: growth factor, matricellular organizer, fibrotic biomarker or molecular target for anti-fibrotic therapy in SSc [J].

Abraham, D. .

RHEUMATOLOGY, 2008, 47 :V8-V9

[2] Overview of pathogenesis of systemic sclerosis [J].

Abraham, D. J. ;

Krieg, T. ;

Distler, J. ;

Distler, O. .

RHEUMATOLOGY, 2009, 48 :3-7

[3] Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies [J].

Agarwal, Pallavi ;

Schulz, Jan-Niklas ;

Blumbach, Katrin ;

Andreasson, Kristofer ;

Heinegard, Dick ;

Paulsson, Mats ;

Mauch, Cornelia ;

Eming, Sabine A. ;

Eckes, Beate ;

Krieg, Thomas .

MATRIX BIOLOGY, 2013, 32 (06) :325-331

[4] Genetics and genomic studies in scleroderma (systemic sclerosis) [J].

Agarwal, Sandeep K. ;

Tan, Filernon K. ;

Arnett, Frank C. .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2008, 34 (01) :17-+

[5] Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis [J].

Akhmetshina, Alfiya ;

Palumbo, Katrin ;

Dees, Clara ;

Bergmann, Christina ;

Venalis, Paulius ;

Zerr, Pawel ;

Horn, Angelika ;

Kireva, Trayana ;

Beyer, Christian ;

Zwerina, Jochen ;

Schneider, Holm ;

Sadowski, Anika ;

Riener, Marc-Oliver ;

MacDougald, Ormond A. ;

Distler, Oliver ;

Schett, Georg ;

Distler, Joerg H. W. .

NATURE COMMUNICATIONS, 2012, 3

[6] Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [J].

Allanore, Yannick ;

Saad, Mohamad ;

Dieude, Philippe ;

Avouac, Jerome ;

Distler, Jorg H. W. ;

Amouyel, Philippe ;

Matucci-Cerinic, Marco ;

Riemekasten, Gabriella ;

Airo, Paolo ;

Melchers, Inga ;

Hachulla, Eric ;

Cusi, Daniele ;

Wichmann, H. -Erich ;

Wichmann, Erich ;

Wipff, Julien ;

Lambert, Jean-Charles ;

Hunzelmann, Nicolas ;

Tiev, Kiet ;

Caramaschi, Paola ;

Diot, Elisabeth ;

Kowal-Bielecka, Otylia ;

Valentini, Gabriele ;

Mouthon, Luc ;

Czirjak, Laszlo ;

Damjanov, Nemanja ;

Salvi, Erika ;

Conti, Costanza ;

Mueller, Martina ;

Mueller-Ladner, Ulf ;

Riccieri, Valeria ;

Ruiz, Barbara ;

Cracowski, Jean-Luc ;

Letenneur, Luc ;

Dupuy, Anne Marie ;

Meyer, Oliver ;

Kahan, Andre ;

Munnich, Arnold ;

Boileau, Catherine ;

Martinez, Maria .

PLOS GENETICS, 2011, 7 (07)

[7] Genetic background of systemic sclerosis: autoimmune genes take centre stage [J].

Allanore, Yannick ;

Dieude, Philippe ;

Boileau, Catherine .

RHEUMATOLOGY, 2010, 49 (02) :203-210

[8] Integrin αvβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1 [J].

Annes, JP ;

Chen, Y ;

Munger, JS ;

Rifkin, DB .

JOURNAL OF CELL BIOLOGY, 2004, 165 (05) :723-734

[9]

[Anonymous], CSH PERSPECT BIOL

[10] Mast Cells Are Dispensable for Normal and Activin-Promoted Wound Healing and Skin Carcinogenesis [J].

Antsiferova, Maria ;

Martin, Caroline ;

Huber, Marcel ;

Feyerabend, Thorsten B. ;

Foerster, Anja ;

Hartmann, Karin ;

Rodewald, Hans-Reimer ;

Hohl, Daniel ;

Werner, Sabine .

JOURNAL OF IMMUNOLOGY, 2013, 191 (12) :6147-6155

← 1 2 3 4 5 6 7 8 9 10 →