Protective Effects of the Carotenoid Zeaxanthin in Experimental Nonalcoholic Steatohepatitis

被引：23

作者：

Chamberlain, Sherman M. ^{[1
]}

Hall, Joshua D. ^{[1
]}

Patel, Jigneshkumar ^{[1
]}

Lee, Jeffrey R. ^{[2
,3
]}

Marcus, Dennis M. ^{[4
]}

Sridhar, Subbaramiah ^{[1
]}

Romero, Maritza J. ^{[5
]}

Labazi, Mohamed ^{[6
]}

Caldwell, Robert W. ^{[5
]}

Bartoli, Manuela ^{[7
]}

机构：

[1] Med Coll Georgia, Dept Med, Gastroenterol Sect, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Pathol, Immunotherapy Ctr, Inst Mol Med & Genet, Augusta, GA 30912 USA

[3] Charlie Norwood Vet Affairs Med Ctr, Dept Pathol, Augusta, GA USA

[4] SE Retina Ctr, Augusta, GA 30908 USA

[5] Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA

[6] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA

[7] Med Coll Georgia, Dept Ophthalmol, Vis Discovery Inst, Augusta, GA 30912 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 07期

关键词：

Fatty liver; NASH; Carotenoid; Zeaxanthin; Oxidative stress; Fibrosis; HEPATIC STEATOSIS; LYCIUM-CHINENSE; ANIMAL-MODELS; TISSUE; LIVER; DIPALMITATE; DISEASE; LUTEIN; SERUM; NASH;

D O I：

10.1007/s10620-009-0824-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fat infiltration and inflammation cause liver injury and fibrosis and may progress to nonalcoholic steatohepatitis (NASH) and end-stage liver disease. Currently, there are no effective treatments for NASH. Zeaxanthin is a carotenoid which has been shown to be preferentially accumulated in the adipose tissue and liver. We hypothesized that treatment with zeaxanthin may decrease oxidative stress in the liver and, possibly, halt the inflammation and fibrosis associated with NASH. Here we tested zeaxanthin effects in preventing progression of liver injury in a model of NASH. Mongolian gerbils, fed a methionine-choline-deficient diet, were treated with different doses of zeaxanthin. We assessed histopathological changes by hematoxylin-eosin and Masson trichrome staining and determined oxidative stress by measuring lipid peroxidation. The obtained results show that zeaxanthin significantly prevented NASH progression by decreasing oxidative stress and liver fibrosis, thus suggesting a potential therapeutic application for this carotenoid in the management of NASH.

引用

页码：1460 / 1464

页数：5

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