Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases

被引：125
|
作者：
Song, Jialin [1 ,2 ]
Ouyang, Yuanming [1 ,2 ]
Che, Junyi [3 ]
Li, Xiaoming [3 ]
Zhao, Yi [3 ]
Yang, Kejia [3 ]
Zhao, Xiaotian [3 ]
Chen, Yinghui [4 ]
Fan, Cunyi [1 ]
Yuan, Weien [3 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai, Peoples R China
[2] Shanghai Univ Med & Hlth, Shanghai Peoples Hosp 6, East Campus, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China
[4] Fudan Univ, Jinshan Hosp, Dept Neurol, Shanghai, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
基金：
中国国家自然科学基金; 上海市自然科学基金;
关键词：
microRNAs; miR-221/222; diseases; diagnosis; prognosis; therapy; biomarker; HUMAN HEPATOCELLULAR-CARCINOMA; REFRACTORY MULTIPLE-MYELOMA; HUMAN COLORECTAL-CARCINOMA; ESTROGEN-RECEPTOR-ALPHA; PROSTATE-CANCER CELLS; BREAST-CANCER; PANCREATIC-CANCER; GASTRIC-CANCER; DOWN-REGULATION; CLINICAL-SIGNIFICANCE;
D O I：
10.3389/fimmu.2017.00056
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221and miR-222 (miR-221/222) are two highly homologous miRNAs, and they are significantly overex-pressed in several types of human diseases. Silencing miR-221/222 could represent a promising approach for therapeutic studies. In the present review, we will describe the potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers in various diseases including cancer and inflammatory diseases.
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页数：9
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