Shaping the nuclear action of NF-κB

被引：1042
作者：
Chen, LF
Greene, WC [1 ]
机构：
[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, Dept Med, San Francisco, CA 94141 USA
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94141 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm1368
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The NF-kappaB/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival. The cytoplasmic regulation of NF-kappaB is well characterized and, recently, significant progress has been made in understanding how its nuclear action is regulated. Post-translational modification of the NF-kappaB subunits as well as histones surrounding the NF-kappaB target genes has a key role in this regulation. Here, we review the important advances that constitute this new and exciting chapter in NF-kappaB biology.
引用
收藏
页码：392 / 401
页数：10
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