Diurnal variations in luminal and stromal areas of choroid in normal eyes

被引:82
作者
Kinoshita, Takamasa [1 ,2 ]
Mitamura, Yoshinori [1 ]
Shinomiya, Kayo [1 ]
Egawa, Mariko [1 ]
Iwata, Akiko [1 ]
Fujihara, Akiko [1 ]
Ogushi, Yoko [1 ]
Semba, Kentaro [1 ]
Akaiwa, Kei [1 ]
Uchino, Eisuke [3 ]
Sonoda, Shozo [3 ]
Sakamoto, Taiji [3 ]
机构
[1] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Ophthalmol, 3-18-15 Kuramoto, Tokushima 7708503, Japan
[2] Sapporo City Gen Hosp, Dept Ophthalmol, Sapporo, Hokkaido, Japan
[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Ophthalmol, Kagoshima, Japan
关键词
Choroid; Imaging; Macula; Physiology; OPTICAL COHERENCE TOMOGRAPHY; CENTRAL SEROUS CHORIORETINOPATHY; HEALTHY-SUBJECTS; AXIAL LENGTH; THICKNESS; DISEASE;
D O I
10.1136/bjophthalmol-2016-308594
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Aims To determine the diurnal variations of the luminal and stromal areas of the choroid in normal eyes. Methods This was a prospective observational study of 38 eyes of 38 normal subjects. The blood pressure, heart rate, intraocular pressure and enhanced depth imaging optical coherence tomographic (EDI-OCT) images were recorded every 3hours between 6:00 and 21:00hours. The horizontal EDI-OCT images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), total cross-sectional choroidal area, the luminal areas, stromal areas and the ratio of luminal area to total choroidal area (L/C ratio) were determined. Results There were significant diurnal variations in the CCT, total choroidal area, luminal area and L/C ratio with the maximum values at 6:00hours and the minimum values at 15:00hours (p<0.001 for the CCT, p=0.011 for the total choroidal area, p<0.001 for the luminal area and p=0.014 for the L/C ratio). There was no significant variation in the stromal area (p=0.216). The range of fluctuation in the CCT was significantly correlated with that in the luminal area and the total choroidal area (p<0.001). However, there was no significant correlation between the fluctuation range in the CCT and that in the stromal area (p=0.095). There was no statistical relationship between the systemic parameters and the choroidal parameters. Conclusions The changes in the luminal area are most likely responsible for the diurnal change in the CCT and subfoveal choroidal area. Trial registration number UMIN000019060, Pre-results.
引用
收藏
页码:360 / 364
页数:5
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