Celiac Disease in Brazilian First-degree Relatives: The Odds Are Five Times Greater for HLA DQ2 Homozygous

被引：5
作者：
Lopes, Leticia H. C. [1 ]
Muniz, Janaina G. [1 ]
Oliveira, Ricardo P. [1 ]
Sdepanian, Vera L. [1 ]
机构：
[1] Univ Fed Sao Paulo, Pediat Dept, Div Pediat Gastroenterol, Escola Paulista Med, Rua Estado Israel,577 Apto 112, BR-04022001 Sao Paulo, Brazil
来源：
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2019年 / 68卷 / 05期
关键词：
celiac disease/diagnosis; celiac disease/epidemiology; family; human leukocyte antigen antigens; symptoms; PREVALENCE; 1ST; RISK;
D O I：
10.1097/MPG.0000000000002251
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
First-degree relatives (FDRs) of 47 outpatients with celiac disease (CD) answered a questionnaire about symptoms related to CD and were investigated for human leukocyte antigen (HLA)-DQ2, DQB1*02 homozygosis, and DQ8 alleles. Genetically susceptible individuals were tested for anti-transglutaminase antibody immunoglobulin A. Seropositive FDR underwent small bowel biopsies. From 114 FDR, 74.5% (n = 85) were positive for DQ2, DQ8, or both haplotypes. Homozygosity of DQB1*02 was found in 11.4% (n = 13) individuals. Three FDR were previously diagnosed with CD. Among the genetically susceptible individuals, 67.1% had at least 1 symptom related to CD. Seropositivity was 8/82 (9.8%), and 4/8 biopsies were compatible with CD. Therefore, the total number of FDR with CD was 6.1% (7/114), 95% confidence interval (1.71, 10.49). Three out of 7 FDR with CD were HLA DQB1*02 homozygous. The odds of being CD is 5 times, 95% confidence interval (0.99, 26.23), greater for HLA DQ B1*02 homozygous in FDR.
引用
收藏
页码：E77 / E80
页数：4
相关论文
共 17 条
[1]  
Martins Rita de Cássia Azevedo, 2010, Arq. Gastroenterol., V47, P257, DOI 10.1590/S0004-28032010000300009
[2]   Primary immunodeficiency disorders: Antibody deficiency [J].
Ballow, M .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (04) :581-591
[3]   Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil [J].
Castro-Antunes, Margarida Maria ;
Crovella, Sergio ;
Cavalcanti Brandao, Lucas Andre ;
Guimaraes, Rafael Lima ;
Farias Almeida Motta, Maria Eugenia ;
Pontes da Silva, Giselia Alves .
CLINICS, 2011, 66 (02) :227-231
[4]   Prevalence of Celiac Disease Among First-degree Relatives of Patients With Celiac Disease [J].
Dogan, Yasar ;
Yildirmaz, Serap ;
Ozercan, Ibrahim Hanifi .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2012, 55 (02) :205-208
[5]   Prevalence of celiac disease in at-risk and not-at-risk groups in the United States - A large multicenter study [J].
Fasano, A ;
Berti, I ;
Gerarduzzi, T ;
Not, T ;
Colletti, RB ;
Drago, S ;
Elitsur, Y ;
Green, PHR ;
Guandalini, S ;
Hill, ID ;
Pietzak, M ;
Ventura, A ;
Thorpe, M ;
Kryszak, D ;
Fornaroli, F ;
Wasserman, SS ;
Murray, JA ;
Horvath, K .
ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (03) :286-292
[6]   Clinical pattern of Celiac disease is still changing [J].
Garampazzi, Andrea ;
Rapa, Anna ;
Mura, Serena ;
Capelli, Antonella ;
Valori, Anna ;
Boldorini, Renzo ;
Oderda, Giuseppina .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2007, 45 (05) :611-614
[7]   The first large population based twin study of coeliac disease [J].
Greco, L ;
Romino, R ;
Coto, I ;
Di Cosmo, N ;
Percopo, S ;
Maglio, M ;
Paparo, F ;
Gasperi, V ;
Limongelli, MG ;
Cotichini, R ;
D'Agate, C ;
Tinto, N ;
Sacchetti, L ;
Tosi, R ;
Stazi, MA .
GUT, 2002, 50 (05) :624-628
[8]   European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease [J].
Husby, S. ;
Koletzko, S. ;
Korponay-Szabo, I. R. ;
Mearin, M. L. ;
Phillips, A. ;
Shamir, R. ;
Troncone, R. ;
Giersiepen, K. ;
Branski, D. ;
Catassi, C. ;
Lelgeman, M. ;
Maki, M. ;
Ribes-Koninckx, C. ;
Ventura, A. ;
Zimmer, K. P. .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2012, 54 (01) :136-160
[9]   HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer:: Results from the European genetics cluster on celiac disease [J].
Karell, K ;
Louka, AS ;
Moodie, SJ ;
Ascher, H ;
Clot, F ;
Greco, L ;
Ciclitira, PJ ;
Sollid, LM ;
Partanen, J .
HUMAN IMMUNOLOGY, 2003, 64 (04) :469-477
[10]   HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease [J].
Margaritte-Jeannin, P ;
Babron, MC ;
Bourgey, M ;
Louka, AS ;
Clot, F ;
Percopo, S ;
Coto, I ;
Hugot, JP ;
Ascher, H ;
Sollid, LM ;
Greco, L ;
Clerget-Darpoux, F .
TISSUE ANTIGENS, 2004, 63 (06) :562-567
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