Transition metal-free C(sp3)-H bond coupling among three methyl groups

被引：60

作者：

Liu, Yufeng ^{[1
]}

Zhan, Xi ^{[1
]}

Ji, Pengyi ^{[1
]}

Xu, Jingwen ^{[1
]}

Liu, Qiang ^{[1
]}

Luo, Weiping ^{[1
]}

Chen, Tieqiao ^{[1
]}

Guo, Cancheng ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 38期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; BAYLIS-HILLMAN REACTION; CARBON-HYDROGEN BONDS; OXIDATIVE ACTIVATION; CATALYZED ARYLATION; AMINO-ACIDS; FUNCTIONALIZATION; ALKYLATION; SP(2); STRATEGY;

D O I：

10.1039/c7cc01309d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A coupling of multiple C(sp(3))-H bonds of the methyl group in methyl ketones with dimethyl sulfoxide is developed. This coupling allows the direct C(sp(3))-H bond coupling among three methyl groups and affords one C-C bond and one CQC bond under transition metal-free conditions. The value-added cyclized 3-methylthiomethyl chroman-4-ones can be synthesized through this method. A plausible mechanism is proposed.

引用

页码：5346 / 5349

页数：4

共 36 条

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