Autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of polycystic; kidney diseases, which are genetic disorders characterized by the abnormal growth of numerous cysts in the kidneys. ADPKD is one of the leading causes of endstage renal failure. It results from mutations in two genes, PKD1 and PKD2, with PKD1 mutations accounting for more than 80% of cases. Currently, there is no cure for ADPKD and traditional treatments have been supportive, aimed at ameliorating associated symptoms and complications. However, the advances in understanding the pathophysiology of this disease will lead to more targeted therapeutic strategies to prevent cyst formation.