Enantioselective Synthesis of Biaryl Atropisomers via Pd/Norbornene-Catalyzed Three-Component Cross-Couplings

被引：103

作者：

Ding, Linlin ^{[1
]}

Sui, Xianwei ^{[1
]}

Gu, Zhenhua ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Ctr Excellence Mol Synth, Dept Chem, 96 Jinzhai Rd, Hefei 230026, Anhui, Peoples R China

来源：

ACS CATALYSIS | 2018年 / 8卷 / 06期

关键词：

cross-coupling palladium; norbornene; atropisomer; asymmetric catalysis; AXIALLY CHIRAL BIARYLS; SUZUKI-MIYAURA REACTION; C-H FUNCTIONALIZATION; ATROPOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; NATURAL-PRODUCTS; ARYL IODIDES; LIGANDS; COMPLEXES;

D O I：

10.1021/acscatal.8b01037

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Three-component cross-coupling cocatalyzed by palladium and norbornene is reported for the synthesis of biaryl atropisomers. This domino reaction gave optimal yield and enantioselectivity with a P,C-type ligand bearing axial chirality and P chiral center. The process showed advantages over traditional cross-coupling because of its step economy and its compatibility with readily available ortho-substituted aryl halides, which could, therefore, be used instead of continuously trisubstituted aryl halides.

引用

页码：5630 / 5635

页数：11

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