Telavancin Is Active against Experimental Aortic Valve Endocarditis Caused by Daptomycin- and Methicillin-Resistant Staphylococcus aureus Strains

被引：7
|
作者：
Abdelhady, Wessam [1 ]
Bayer, Arnold S. [1 ,2 ,3 ]
Gonzales, Rachelle [1 ]
Li, Liang [1 ]
Xiong, Yan Q. [1 ,2 ,3 ]
机构：
[1] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA
[2] LAC Harbor UCLA Med Ctr, Div Infect Dis, Torrance, CA USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期
关键词：
TLV; DAPr MRSA; endocarditis; daptomycin resistance; MRSA; telavancin; infective endocarditis; IN-VITRO ACTIVITY; RABBIT MODEL; EFFICACY; VANCOMYCIN; BACTEREMIA; MECHANISMS;
D O I：
10.1128/AAC.01877-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the efficacy of telavancin (TLV) and daptomycin (DAP) in an experimental rabbit endocarditis model caused by two clinically derived daptomycin-resistant (DAPr) methicillin-resistant Staphylococcus aureus (MRSA) strains. TLV treatment significantly reduced MRSA densities in all target tissues and increased the percentage of these organs rendered culture negative compared to those with the untreated control or DAP-treated animals. These results demonstrate that TLV has potent in vivo efficacy against DAPr MRSA isolates in this invasive endovascular infection model.
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页数：5
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