Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease: Review and Meta-Analysis

被引：56

作者：

Athanasaki, Athanasia ^{[1
]}

Melanis, Konstantinos ^{[2
]}

Tsantzali, Ioanna ^{[2
]}

Stefanou, Maria Ioanna ^{[2
]}

Ntymenou, Sofia ^{[1
]}

Paraskevas, Sotirios G. ^{[2
]}

Kalamatianos, Theodosis ^{[3
]}

Boutati, Eleni ^{[4
]}

Lambadiari, Vaia ^{[4
]}

Voumvourakis, Konstantinos, I ^{[2
]}

Stranjalis, George ^{[3
]}

Giannopoulos, Sotirios ^{[2
]}

Tsivgoulis, Georgios ^{[2
]}

Paraskevas, George P. ^{[2
]}

机构：

[1] Evangelismos Med Ctr, Dept Neurol, Athens 10676, Greece

[2] Natl & Kapodistrian Univ Athens, Attikon Univ Gen Hosp, Sch Med, Dept Neurol 2, Athens 12462, Greece

[3] Natl & Kapodistrian Univ Athens, Evangelismos Hosp, Sch Med, Dept Neurosurg 1, Athens 10676, Greece

[4] Natl & Kapodistrian Univ Athens, Attikon Univ Gen Hosp, Sch Med, Dept Internal Med 2, Athens 12462, Greece

来源：

BIOMEDICINES | 2022年 / 10卷 / 04期

关键词：

type 2 diabetes mellitus; Alzheimer's disease; common mechanisms; MILD COGNITIVE IMPAIRMENT; ENDOPLASMIC-RETICULUM STRESS; BRAIN INSULIN-RESISTANCE; AMYLOID-BETA PEPTIDE; A-BETA; VASCULAR DEMENTIA; AUTOPHAGY; INFLAMMATION; RECEPTOR; ACTIVATION;

D O I：

10.3390/biomedicines10040778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is the most common type of dementia, reaching 60-80% of case totals, and is one of the major global causes of the elderly population's decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer's disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer's disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases.

引用

页数：17

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