Preparation of the chitosan/poly(glutamic acid)/alginate polyelectrolyte complexing hydrogel and study on its drug releasing property

被引:97
作者
Chen, Yu [1 ]
Yan, Xiaoting [1 ]
Zhao, Jian [1 ]
Feng, Huaiyu [1 ]
Li, Puwang [2 ]
Tong, Zongrui [1 ]
Yang, Ziming [1 ,2 ]
Li, Sidong [3 ]
Yang, Jueying [1 ]
Jin, Shaohua [1 ]
机构
[1] Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China
[2] Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China
[3] Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China
关键词
Semi-dissolution/acidification/sol-gel transition; Polyelectrolyte complex; Hydrogel; Natural polymer; Piroxicam; Release; CHITOSAN HYDROGEL; PIROXICAM; DELIVERY; SOLUBILITY; STABILITY; MEMBRANES; POLYMER; ACID);
D O I
10.1016/j.carbpol.2018.02.065
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
In the current study, a novel semi-dissolution/acidification/sol-gel transition (SD-A-SGT) method was explored for the preparation of polyelectrolyte complexing (PEC) composite hydrogels with natural polymers only. A chitosan (CS) powder was uniformly dispersed in a solution of poly(glutamic acid) (PGA) and alginate (SA) to form a semi-dissolved slurry mixture that was then exposed to an gaseous acidic atmosphere. CS was gradually dissolved and interacted with PGA and SA to form a CS/PGA/SA PEC composite hydrogel with a homogeneous structure. The SD-A-SGT procedure was able to overcome the shortcomings of direct mixing method via the PEC interaction. The effects of the hydrogel composition on its structure and properties were investigated by FTIR, XRD, rheology study, XPS, SEM, and swelling kinetics. The drug delivery performance of the CS/PGA/SA hydrogel was explored using piroxicam (PXC) as a model drug. PXC was in situ embedded in the hydrogel by the SD-A-SGT method. The hydrogel exhibited pH responsive drug release behaviors that were affected by the hydrogel composition. In all, the SD-A-SGT method for preparing PEC composite hydrogels has a great application potential in constructing the CS based hydrogels as medical materials.
引用
收藏
页码:8 / 16
页数:9
相关论文
共 29 条
[1]   Microporous PDMAEMA-based stimuli-responsive hydrogel and its application in drug release [J].
Chen, Yi ;
Liu, Wenyong ;
Zeng, Guangsheng ;
Liu, YueJun .
JOURNAL OF APPLIED POLYMER SCIENCE, 2017, 134 (38)
[2]   Preparation, property of the complex of carboxymethyl chitosan grafted copolymer with iodine and application of it in cervical antibacterial biomembrane [J].
Chen, Yu ;
Yang, Yumin ;
Liao, Qingping ;
Yang, Wei ;
Ma, Wanfeng ;
Zhao, Jian ;
Zheng, Xionggao ;
Yang, Yang ;
Chen, Rui .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 67 :247-258
[3]   Preparation and study on the volume phase transition properties of novel carboxymethyl chitosan grafted polyampholyte superabsorbent polymers [J].
Chen, Yu ;
Tang, Huanlin ;
Liu, Yang ;
Tan, Huimin .
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2016, 59 :569-577
[4]   Synthesis and characterization of a novel superabsorbent polymer of N,O-carboxymethyl chitosan graft copolymerized with vinyl monomers [J].
Chen, Yu ;
Liu Yun-fei ;
Tan Hui-min ;
Jiang Jian-xin .
CARBOHYDRATE POLYMERS, 2009, 75 (02) :287-292
[5]   Solubility, solution thermodynamics, and preferential solvation of piroxicam in ethyl acetate plus ethanol mixtures [J].
Cristancho, Diana M. ;
Jouyban, Abolghasem ;
Martinez, Fleming .
JOURNAL OF MOLECULAR LIQUIDS, 2016, 221 :72-81
[6]  
[郝志峰 Hao Zhifeng], 2003, [光谱实验室, Chinese Journal of Spectroscopy laboratory], V20, P799
[7]   A smart aminoglycoside hydrogel with tunable gel degradation, on-demand drug release, and high antibacterial activity [J].
Hu, Jingjing ;
Quan, Yanchun ;
Lai, Yuping ;
Zheng, Zhao ;
Hu, Zhiqi ;
Wang, Xinyu ;
Dai, Tianjiao ;
Zhang, Qiang ;
Cheng, Yiyun .
JOURNAL OF CONTROLLED RELEASE, 2017, 247 :145-152
[8]   A novel injectable chitosan/polyglutamate polyelectrolyte complex hydrogel with hydroxyapatite for soft-tissue augmentation [J].
Ji, Dian-Yu ;
Kuo, Tzong-Fu ;
Wu, Hong-Da ;
Yang, Jen-Chang ;
Lee, Shang-Yang .
CARBOHYDRATE POLYMERS, 2012, 89 (04) :1123-1130
[9]   Polyelectrolyte complex hydrogel composed of chitosan and poly(γ-glutamic acid) for biological application:: Preparation, physical properties, and cytocompatibility [J].
Kang, Hahk-Soo ;
Park, Se-Hoon ;
Lee, Young-Gi ;
Son, Tae-Il .
JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 103 (01) :386-394
[10]   Reversible self-bending soft hydrogel microstructures with mechanically optimized designs [J].
Kim, Jongmin ;
Kim, Cheolgyu ;
Song, YoungShin ;
Jeong, Seong-Geun ;
Kim, Taek-Soo ;
Lee, Chang-Soo .
CHEMICAL ENGINEERING JOURNAL, 2017, 321 :384-393