Microfluidic transmission surface plasmon resonance enhancement for biosensor applications

被引：12

作者：

Lertvachirapaiboon, Chutiparn ^{[1
]}

Baba, Akira ^{[1
]}

Ekgasit, Sanong ^{[2
]}

Shinbo, Kazunari ^{[1
]}

Kato, Keizo ^{[1
]}

Kaneko, Futao ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan

[2] Chulalongkorn Univ, Dept Chem, Sensor Res Unit, Fac Sci, Bangkok 10330, Thailand

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS | 2017年 / 56卷 / 01期

关键词：

EXTRAORDINARY OPTICAL-TRANSMISSION; ELECTROCHEMICAL GLUCOSE SENSORS; NANOHOLE ARRAYS; HOLE ARRAYS; FILMS; LIGHT; SPECTROSCOPY; OXIDASE; SILVER; CHIP;

D O I：

10.7567/JJAP.56.017002

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The microfluidic transmission surface plasmon resonance (MTSPR) constructed by assembling a gold-coated grating substrate with a microchannel was employed for biosensor application. The transmission surface plasmon resonance spectrum obtained from the MTSPR sensor chip showed a strong and narrow surface plasmon resonance (SPR) peak located between 650 and 800 nm. The maximum SPR excitation was observed at an incident angle of 35 degrees. The MTSPR sensor chip was employed for glucose sensor application. Gold-coated grating substrates were functionalized using 3-mercapto-1-propanesulfonic acid sodium salt and subsequently functionalized using a five-bilayer poly(allylamine hydrochloride)/ poly(sodium 4-styrenesulfonate) to facilitate the coupling/ decoupling of the surface plasmon and to prepare a uniform surface for sensing. The detection limit of our developed system for glucose was 2.31 mM. This practical platform represents a high possibility of further developing several biomolecules, multiplex systems, and a point-of-care assay for practical biosensor applications. (C) 2017 The Japan Society of Applied Physics

引用

页数：4

共 34 条

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