The Wound Healing Effect of Adipose Tissue-Derived Stem Cells(ADSCs) in Radiation-Induced Skin Injury

被引：0

作者：

Heo, Chan Yeong ^{[1
,2
]}

Lee, Eun Hye ^{[1
,2
]}

Kang, Hye In ^{[1
,2
]}

Kim, In Ah ^{[3
]}

Eun, Seok Chan ^{[1
,2
]}

Baek, Rong Min ^{[1
,2
]}

Minn, Kyung Won ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Med, Plast Surg Res Inst, Dept Plast Surg, Seoul 110744, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Dept Radiat Oncol, Songnam 463707, Gyeonggi Do, South Korea

[3] Seoul Natl Univ, Bundang Hosp, Dept Plast Surg, Songnam 463707, Gyeonggi Do, South Korea

来源：

TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2009年 / 6卷 / 4-11期

关键词：

Adipose tissue-drived stem cells; radiation; wound; CELLS; DAMAGE; MODEL;

D O I：

暂无

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Radiation-induced skin wound is a unwanted complication of radiation therapy in cancer patients. Because a putative potential stem cell population within the adipose tissue has been found to possess therapeutic potentials, we authors sought to determine the effect of adipose tissue-derived stem cells(ADSCs) oil radiation-induce skin wound. Sprague-Dawley rats were divided into two groups. Adipose tissue-derived stein cells were isolated from the inguinal fat pads and expanded ex vivo, for three passages. All groups received 25 Gy of gamma irradiation as a single dose to the back of the rats using a cobalt-60 teletherapy unit. After four weeks of radiation, syngeneic ADSCs were delivered into the subcutaneous area of irradiated wounded skin area in experimental group. Acute skin reactions were assessed and at the endpoint of the study. Light microscopic findings were assessed. Clinically and histopathologically, radiation skin reactions were lower than control group(p<0.05). ADSCs was found to be efficacious in preventing epidermal atrophy, dermal degeneration and hair follicle atrophy. In conclusion, ADSCs could be used as useful cell therapeutics to repair and regenerate the wound of irradiation damage.

引用

页码：1019 / 1022

页数：4

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