Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments

被引：78

作者：

Renard, Justine ^{[1
,2
]}

Norris, Christopher ^{[1
,2
]}

Rushlow, Walter ^{[1
,2
,3
]}

Laviolette, Steven R. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Western Ontario, Schulich Sch Med & Dent, Addict Res Grp, London, ON N6C 5A1, Canada

[2] Univ Western Ontario, Schulich Sch Med & Dent, Dept Anat & Cell Biol, London, ON N6C 5A1, Canada

[3] Univ Western Ontario, Schulich Sch Med & Dent, Dept Psychiat, London, ON N6C 5A1, Canada

[4] Univ Western Ontario, Schulich Sch Med & Dentistty, Dept Psychol, London, ON N6C 5A1, Canada

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2017年 / 75卷

基金：

加拿大健康研究院;

关键词：

Cannabidiol; Dopamine; Schizophrenia; Post-traumatic stress disorder; Pharmacotherapy; HIGH-POTENCY CANNABIS; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; PARANOID SCHIZOPHRENIA; PREPULSE INHIBITION; CEREBROSPINAL-FLUID; ANANDAMIDE LEVELS; 5-HT1A RECEPTORS; PSYCHOSIS; RELEASE;

D O I：

10.1016/j.neubiorev.2017.02.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Growing clinical and pre-clinical evidence points to a critical role for cannabidiol (CBD), the largest phytochemical component of cannabis, as a potential pharmacotherapy for various neuropsychiatric disorders. In contrast to delta-9-tetrahydrocannabinol (THC), which is associated with acute and neurodevelopmental pro-psychotic side-effects, CBD possesses no known psychoactive or dependence-producing properties. However, evidence has demonstrated that CBD strongly modulates the mesolimbic dopamine (DA) system and may possess promising anti-psychotic properties. Despite the psychotropic differences between CBD and THC, little is known regarding their molecular and neuronal effects on the mesolimbic DA system, nor how these differential effects may relate to their potential pro vs. anti-psychotic properties. This review summarizes clinical and pre-clinical evidence demonstrating CBD's modulatory effects on DA activity states within the mesolimbic pathway, functional interactions with the serotonin 5-HT1A receptor system, and their downstream molecular signaling effects. Together with clinical evidence showing that CBD may normalize affective and cognitive deficits associated with schizophrenia, CBD may represent a promising treatment for schizophrenia, acting through novel molecular and neuronal mesolimbic substrates. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：157 / 165

页数：9

共 79 条

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