Which Factors Contribute to False-Positive, False-Negative, and Invalid Results in Fetal Fibronectin Testing in Women with Symptoms of Preterm Labor?

被引：2

作者：

Bruijn, Merel M. C. ^{[1
]}

Hermans, Frederik J. R. ^{[1
]}

Vis, Jolande Y. ^{[2
]}

Wilms, Femke F. ^{[3
]}

Oudijk, Martijn A. ^{[1
]}

Kwee, Anneke ^{[4
]}

Porath, Martina M. ^{[5
]}

Oei, Guid ^{[5
]}

Scheepers, Hubertina C. J. ^{[6
]}

Spaanderman, Marc E. A. ^{[6
]}

Bloemenkamp, Kitty W. M. ^{[7
]}

Haak, Monique C. ^{[7
]}

Bolte, Antoinette C. ^{[8
]}

Vandenbussche, Frank P. H. A. ^{[8
]}

Woiski, Mallory D. ^{[8
]}

Bax, Caroline J. ^{[9
]}

Cornette, Jerome M. J. ^{[10
]}

Duvekot, Johannes J. ^{[10
]}

Bijvank, Bas W. A. N. I. J. ^{[11
]}

van Eyck, Jim ^{[11
]}

Franssen, Maureen T. M. ^{[12
]}

Sollie, Krystyna M. ^{[12
]}

van der Post, Joris A. M. ^{[1
]}

Bossuyt, Patrick M. M. ^{[13
]}

Kok, Marjolein ^{[1
]}

Mol, Ben W. J. ^{[14
,15
]}

van Baaren, Gert-Jan ^{[1
]}

机构：

[1] Acad Med Ctr, Dept Obstet & Gynecol, POB 22660, NL-1100 DD Amsterdam, Netherlands

[2] Univ Med Ctr Utrecht, Dept Clin Chem & Hematol, Utrecht, Netherlands

[3] Catharina Hosp, Dept Obstet & Gynecol, Eindhoven, Netherlands

[4] Univ Med Ctr Utrecht, Dept Obstet & Gynecol, Utrecht, Netherlands

[5] Maxima Med Ctr, Dept Obstet & Gynecol, Veldhoven, Netherlands

[6] Univ Hosp Maastricht, Dept Obstet & Gynecol, Maastricht, Netherlands

[7] Leiden Univ, Med Ctr, Dept Obstet, Leiden, Netherlands

[8] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynecol, Nijmegen, Netherlands

[9] Vrije Univ Amsterdam, Med Ctr, Dept Obstet & Gynecol, Amsterdam, Netherlands

[10] Erasmus MC, Dept Obstet & Gynecol, Rotterdam, Netherlands

[11] Isala Clin, Dept Obstet & Gynecol, Zwolle, Netherlands

[12] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands

[13] Acad Med Ctr, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands

[14] Univ Adelaide, Robinson Res Inst, Sch Med, Adelaide, SA, Australia

[15] South Australian Hlth & Med Res Inst Adelaide Aus, Adelaide, SA, Australia

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2017年 / 34卷 / 03期

关键词：

fetal fibronectin; preterm delivery; prediction; external factors; MISSING VALUES; PHARMACOKINETICS; IMPUTATION; FDC-6;

D O I：

10.1055/s-0036-1585466

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective We assessed the influence of external factors on false-positive, false negative, and invalid fibronectin results in the prediction of spontaneous delivery within 7 days. Methods We studied symptomatic women between 24 and 34 weeks' gestational age. We performed uni- and multivariable logistic regression to estimate the effect of external factors (vaginal soap, digital examination, transvaginal sonography, sexual intercourse, vaginal bleeding) on the risk of false-positive, false-negative, and invalid results, using spontaneous delivery within 7 days as the outcome. Results Out of 708 women, 237 (33%) had a false-positive result; none of the factors showed a significant association. Vaginal bleeding increased the proportion of positive fetal fibronectin (fFN) results, but was significantly associated with a lower risk of false positive test results (odds ratio [OR], 0.22; 95% confidence intervals [CI], 0.12-0.39). Ten women (1%) had a false-negative result. None of the investigated factors was significantly associated with a significantly higher risk of false-negative results. Twenty-one tests (3%) were invalid; only vaginal bleeding showed a significant association (OR, 4.5; 95% CI, 1.7-12). Conclusion The effect of external factors on the performance of qualitative fFN testing is limited, with vaginal bleeding as the only factor that reduces its validity.

引用

页码：234 / 239

页数：6