Cu(II)-Mediated C-H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles

被引：320

作者：

Shang, Ming ^{[1
]}

Sun, Shang-Zheng ^{[1
]}

Dai, Hui-Xiong ^{[1
]}

Yu, Jin-Quan ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 09期

关键词：

CARBON-HYDROGEN BONDS; CROSS-COUPLING REACTIONS; AROMATIC CARBOXAMIDES; CATALYZED ARYLATION; ARYLBORONIC ACIDS; CUPRIC ACETATE; ACTIVATION; PALLADIUM; INHIBITORS; ARYL;

D O I：

10.1021/ja412880r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Cu(OAc)(2)-mediated C-H amidation and amination of arenes and heteroarenes has been developed using a readily removable directing group. A wide range of sulfonamides, amides, and anilines function as amine donors in this reaction. Heterocycles present in both reactants are tolerated, making this a broadly applicable method for the synthesis of a family of inhibitors including 2-benzamidobenzoic acids and N-phenylaminobenzoates.

引用

页码：3354 / 3357

页数：4

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