The Role of Inflammation in the Progression of Ocular Surface Damage in Children Following Allogeneic Haematopoietic Cell Transplantation

被引:0
作者
Kurpinska, M. [1 ]
Turno-Krecicka, A. [1 ]
Zajac-Pytrus, H. [1 ]
Dziegiel, P. [3 ]
Misiuk-Hojlo, M. [1 ]
Gorczynska, E. [2 ]
机构
[1] Wroclaw Med Univ, Dept Ophthalmol, PL-50556 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept Paediat Bone Marrow Transplantat Oncol & Hae, PL-50556 Wroclaw, Poland
[3] Wroclaw Med Univ, Dept Histol & Embryol, PL-50556 Wroclaw, Poland
关键词
impression cytology; stem cell allotransplantation; HLA-DR expression; conjunctiva; VERSUS-HOST-DISEASE; DRY EYE; HLA-DR; EXPRESSION; PATHOGENESIS; FIBROBLASTS; CONJUNCTIVA;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aim of the study was to evaluate HLA-DR expression and cellular morphology of the conjunctival epithelium cells in children who underwent haematopoietic cell transplantation, and to assess the relation between HLA-DR expression and cellular morphology. Impression cytology with staining was used to visualize epithelium cells, whereas immunohistochemistry was applied to assess HLA-DR expression. Elevated HLA-DR expression and increased cytological abnormalities were observed in the study group when compared to the controls. An increase in HLA-DR expression was accompanied by a decrease in the number of eyes with normal epithelium morphology together with the increase in squamous metaplasia features. We can conclude that inflammation of conjunctiva can follow stem cell allotransplantation. Ocular surface inflammation may lead to squamous metaplasia of the conjunctiva.
引用
收藏
页码:139 / 145
页数:7
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