Vascular smooth muscle cell senescence in atherosclerosis

被引：167

作者：

Gorenne, Isabelle ^{[1
]}

Kavurma, Mary ^{[1
]}

Scott, Stephen ^{[1
]}

Bennett, Martin ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Div Cardiovasc Med, Cambridge CB2 2QQ, England

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 72卷 / 01期

关键词：

atherosclerosis; vascular smooth muscle; cell senescence; ageing;

D O I：

10.1016/j.cardiores.2006.06.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Markers of cell senescence have been identified in both the blood and vessel wall of patients with atherosclerosis. In particular, vascular smooth muscle cells (VSMCs) derived from human plaques show numerous features of senescence both in culture and in vivo. This review summarises the evidence for VSMC senescence in atherosclerosis, and outlines the mechanisms and triggers leading to their senescence. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：9 / 17

页数：9

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