Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon

被引：14
作者：
Dias, G. A. S. [1 ]
Yoshikawa, G. T. [2 ]
Koyama, R. V. L. [3 ]
Fujihara, S. [3 ]
Martins, L. C. S. [4 ]
Medeiros, R. [1 ]
Quaresma, J. A. S. [3 ]
Fuzii, H. T. [1 ]
机构：
[1] Fed Univ Para, Nucleo Med Trop, Ave Generalissimo Deodoro, BR-66055240 Belem, Para, Brazil
[2] Fed Univ Para, Inst Ciencias Saude, BR-66055240 Belem, Para, Brazil
[3] Univ Estado Para, Ctr Ciencias Biol & Saude, Belem, Para, Brazil
[4] Univ Amazonia, Ctr Ciencias Biol & Saude, Belem, Para, Brazil
来源：
SPINAL CORD | 2016年 / 54卷 / 02期
关键词：
MODIFIED ASHWORTH SCALE; INTRARATER RELIABILITY; MUSCLE SPASTICITY; PROVIRAL LOAD; INTERRATER; INFECTION; LIMB;
D O I：
10.1038/sc.2015.112
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Study design: A cross-sectional observational study was conducted. Objective: The aim was to analyze the clinical-functional profile of patients diagnosed with HTLV-1 (human T-lymphotropic virus type 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in the Amazon region. Setting: Reference center for HTLV in the city of Belem, state of Para, Brazil. Methods: Muscle strength, muscle tone, balance and the need for gait assistance among patients with HAM/TSP were evaluated. Results: Among the 82 patients infected with HTLV-1, 27 (10 men and 17 women) were diagnosed with HAM/TSP. No statistically significant difference in muscle tone or strength was found between the lower limbs. Muscle weakness and spasticity were predominant in the proximal lower limbs. Patients with HAM/TSP are at a high risk of falls (P=0.03), and predominantly use either a cane or a crutch on one side as a gait-assistance device (P=0.02). Conclusion: Patients with HAM/TSP exhibit a similar clinical pattern of muscle weakness and spasticity, with a high risk of falls, requiring gait-assistance devices.
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收藏
页码：154 / 157
页数：4
相关论文
共 26 条
[1]  
Ansari NN, 2008, NEUROREHABILITATION, V23, P231
[2]   The HTLV-1 neurological complex [J].
Araujo, Abelardo Q. C. ;
Silva, Marcus Tulius T. .
LANCET NEUROLOGY, 2006, 5 (12) :1068-1076
[3]   INTERRATER RELIABILITY OF A MODIFIED ASHWORTH SCALE OF MUSCLE SPASTICITY [J].
BOHANNON, RW ;
SMITH, MB .
PHYSICAL THERAPY, 1987, 67 (02) :206-207
[4]   Proviral load and the balance of serum cytocines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) [J].
Borges Starling, Ana Lucia ;
Martins-Filho, Olindo Assis ;
Lambertucci, Jose Roberto ;
Labanca, Ludimila ;
de Souza Pereira, Silvio Roberto ;
Teixeira-Carvalho, Andrea ;
Martins, Marina Lobato ;
Ribas, Joao Gabriel ;
Carneiro-Proietti, Anna Barbara F. ;
Goncalves, Denise Utsch .
ACTA TROPICA, 2013, 125 (01) :75-81
[5]  
Cooper Sarah A, 2009, Pract Neurol, V9, P16, DOI 10.1136/jnnp.2008.167155
[6]   Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome [J].
Costa, Davi Tanajura ;
Muniz Alves dos Santos, Andre Luiz ;
de Castro, Neviton Matos ;
de Siqueira, Isadora Cristina ;
de Carvalho Filho, Edgar Marcelino ;
Glesby, Marshall Jay .
ARQUIVOS DE NEURO-PSIQUIATRIA, 2012, 70 (04) :252-256
[7]   Proposal for diagnostic criteria of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) [J].
De Castro-Costa, Carlos M. ;
Araujo, Abelardo Q. C. ;
Barreto, Marcio M. ;
Takayanagui, Osvaldo M. ;
Sohler, Marzia P. ;
Da Silva, Eduardo L. M. ;
De Paula, Sonia M. B. ;
Ishak, Ricardo ;
Ribas, Joao G. R. ;
Rovirosa, Luis C. ;
Carton, Herwig ;
Gotuzzo, Eduardo ;
Hall, William W. ;
Montano, Silvia ;
Murphy, Edward L. ;
Oger, Joel ;
Remondegui, Carlos ;
Taylor, Graham P. .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2006, 22 (10) :931-935
[8]   Falls in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) [J].
Facchinetti, L. D. ;
Araujo, A. Q. ;
Chequer, G. L. ;
de Azevedo, M. F. ;
de Oliveira, R. V. C. ;
Lima, M. A. .
SPINAL CORD, 2013, 51 (03) :222-225
[9]   HUMAN T CELL LYMPHOTROPIC VIRUS (HTLV)1: WHEN SHOULD INFECTION BE SUSPECTED? [J].
Ferreira Romanelli, Luiz Claudio ;
Caramelli, Paulo ;
de Freitas Carneiro Proietti, Anna Barbara .
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2010, 56 (03) :340-347
[10]   Disability and determinants of gait performance in tropical spastic paraparesis/HTLV-I associated myelopathy (HAM/TSP) [J].
Franzoi, A. C. ;
Araujo, A. Q. C. .
SPINAL CORD, 2007, 45 (01) :64-68
123