Reduction of CD4+CD25+ regulatory T-cells in migraine: Is migraine an autoimmune disorder?

被引：40

作者：

Arumugam, Murugesan ^{[1
]}

Parthasarathy, Varadarajan ^{[1
]}

机构：

[1] Annamalai Univ, Dept Pharm, Annamalainagar, India

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2016年 / 290卷

关键词：

Migraine; Autoimmunity; CD4(+); CD8(+); CD4(+)D25(+); CD4:CD8 ratio; PERIPHERAL-BLOOD; LYMPHOCYTE SUBSETS; PLASMA CYTOKINES; IMMUNE-SYSTEM; EXPRESSION; CD8; COUNTS; FOXP3; IMMUNODEFICIENCY; INTERLEUKIN-10;

D O I：

10.1016/j.jneuroim.2015.11.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Migraine is believed to be a chronic neurological disorder with the exact aetiology being unknown. But, there is a debate on the role of immune dysfunction in migraine pathophysiology. Hence, authors made a debut attempt to explore the link between lymphocyte subset populations and migraine. A significant increase in CD4(+) and decrease in CD8(+) population were observed in migraine patients compared to healthy volunteers. Interestingly, the immunoregulator CD4(+)CD25(+) levels were less in migraine patients compared to the healthy volunteers. The results of the present study indicate that failure of immunoregulation could be implicated in the pathophysiology of migraine. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：54 / 59

页数：6

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