Ophiobolin-Type Sesterterpenoids from the Mangrove Endophytic Fungus Aspergillus sp. ZJ-68

被引：44

作者：

Cai, Runlin ^{[1
]}

Jiang, Hongming ^{[1
]}

Mo, Yaling ^{[1
]}

Guo, Huixian ^{[2
]}

Li, Chunyuan ^{[3
]}

Long, Yuhua ^{[2
]}

Zang, Zhenming ^{[1
]}

She, Zhigang ^{[1
,4
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China

[2] South China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China

[3] South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China

[4] South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CYTOTOXIC SESTERTERPENES; METABOLITES; INHIBITORS; DERIVATIVES; COMPLEXES;

D O I：

10.1021/acs.jnatprod.9b00462

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eleven new ophiobolin-type sesterterpenoids, asperophiobolins A-K (1-11), along with 12 known analogues (12-23) were isolated from the cultures of the mangrove endophytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were elucidated through spectroscopic analyses, and their absolute configurations were assigned by a combination of Mo-2(AcO)(4)-induced electronic circular dichroism spectra and quantum chemical calculations. Asperophiobolins A-D (1-4) represent the first examples possessing a five-membered lactam unit between C-5 and C-21 in ophiobolin derivatives. In the bioactivity assays, compounds 8-10 and 14-17 exhibited inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells with IC50 values ranging from 9.6 to 25 mu M, and compound 8 was found to show comparable inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase B with an IC50 value of 19 mu M.

引用

页码：2268 / 2278

页数：11

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