Serum Copper is not Altered in Frontotemporal Lobar Degeneration

被引：9

作者：

Squitti, Rosanna ^{[1
]}

Fostinelli, Silvia ^{[1
]}

Siotto, Mariacristina ^{[2
]}

Ferrari, Clarissa ^{[3
]}

Binetti, Giuliano ^{[1
,4
]}

Benussi, Luisa ^{[1
]}

Rongioletti, Mauro ^{[5
]}

Ghidoni, Roberta ^{[1
]}

机构：

[1] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, I-25125 Brescia, Italy

[2] IRCCS Fondaz Don Carlo Gnocchi, Milan, Italy

[3] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Stat Serv, Brescia, Italy

[4] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, MAC Memory Ctr, Brescia, Italy

[5] Fatebenefratelli Hosp, Dept Lab Med, Res & Dev Div, San Giovanni Calibita, Rome, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 63卷 / 04期

关键词：

Ceruloplasmin; copper; frontotemporal dementia; non-ceruloplasmin copper; serum; ALZHEIMERS-DISEASE; DIAGNOSTIC-CRITERIA; CERULOPLASMIN; DEMENTIA; IRON; METAANALYSIS; HERITABILITY; DYSFUNCTION; GENETICS; INSIGHT;

D O I：

10.3233/JAD-171074

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Meta-analyses show copper dyshomeostasis in Alzheimer's disease. However, a study evaluating copper changes in other neurodegenerative forms of dementia has not yet been performed. In this study, we assessed copper, ceruloplasmin, copper not bound to ceruloplasmin, and copper to ceruloplasmin ratio in 85 patients affected by frontotemporal lobar degeneration (FTLD) and 55 healthy controls. Data were analyzed through multivariate ANOVA models taking into account age and sex as covariates and the stratification for FTLD variants, after calculating power analysis to ensure the reliability of the conclusions drawn. The study revealed no difference between the groups.

引用

页码：1427 / 1432

页数：6

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