Synthesis and Antibacterial Activities of Bis-1,3,4-oxadiazoline derivatives

被引：0
|
作者：
Li, De-Jiang [1 ]
Dan, Fei-Jun [1 ]
Fu, He-Qing [2 ]
机构：
[1] China Three Gorges Univ, Coll Chem & Life Sci, Yichang 443002, Peoples R China
[2] S China Univ Technol, Res Inst Chem Engn, Guangzhou 510640, Peoples R China
来源：
HETEROCYCLIC COMMUNICATIONS | 2008年 / 14卷 / 06期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dimethyl terephthalate (1) was reacted with 80% hydrazine hydrate in refluxing methanol for 12 h to afford terephthalate dihydrazide (2). Condensation of 2 with aromatic aldehydes afforded corresponding hydrazones 3a-3j. Cyclization of 3a-3j with acetic anhydride in refluxing for 4-5 h afforded bis-1,3,4-oxadiazoline derivatives(4a-4j). The structures of 4a-4j were characterized by elementary analyses, IR, H-1 NMR, and MS spectroscopy. The preliminary antibacterial tests showed that most of them were effective against S.aureus.
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页码：465 / 468
页数：4
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