Synthesis and Antibacterial Activities of Bis-1,3,4-oxadiazoline derivatives

被引：0

作者：

Li, De-Jiang ^{[1
]}

Dan, Fei-Jun ^{[1
]}

Fu, He-Qing ^{[2
]}

机构：

[1] China Three Gorges Univ, Coll Chem & Life Sci, Yichang 443002, Peoples R China

[2] S China Univ Technol, Res Inst Chem Engn, Guangzhou 510640, Peoples R China

来源：

HETEROCYCLIC COMMUNICATIONS | 2008年 / 14卷 / 06期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dimethyl terephthalate (1) was reacted with 80% hydrazine hydrate in refluxing methanol for 12 h to afford terephthalate dihydrazide (2). Condensation of 2 with aromatic aldehydes afforded corresponding hydrazones 3a-3j. Cyclization of 3a-3j with acetic anhydride in refluxing for 4-5 h afforded bis-1,3,4-oxadiazoline derivatives(4a-4j). The structures of 4a-4j were characterized by elementary analyses, IR, H-1 NMR, and MS spectroscopy. The preliminary antibacterial tests showed that most of them were effective against S.aureus.

引用

页码：465 / 468

页数：4

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