Chloride imbalance is involved in the pathogenesis of optic neuritis in neuromyelitis optica

被引：5
作者：
Akaishi, Tetsuya [1 ,2 ]
Takahashi, Toshiyuki [1 ,2 ]
Himori, Noriko [3 ]
Takeshita, Takayuki [3 ]
Nakazawa, Toru [3 ]
Aoki, Masashi [1 ]
Nakashima, Ichiro [4 ]
机构：
[1] Tohoku Univ, Dept Neurol, Grad Sch Med, Sendai, Miyagi, Japan
[2] Yonezawa Natl Hosp, Dept Neurol, Yonezawa, Yamagata, Japan
[3] Tohoku Univ, Dept Ophthalmol, Grad Sch Med, Sendai, Miyagi, Japan
[4] Tohoku Med & Pharmaceut Univ, Dept Neurol, Sendai, Miyagi, Japan
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 320卷
关键词：
Neuromyelitis optica; Chloride imbalance; Quotient of chloride; Optic neuritis; Visual prognosis; SPECTRUM DISORDERS; ANTIBODY;
D O I：
10.1016/j.jneuroim.2018.03.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (Q(Cl)) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between Q(Cl) and the length of ON-lesion. The visual prognosis also showed a positive correlation with Q(Cl) in the acute phase (R = 0.58; p < 0.05). These results support the theory that chloride imbalance between serum and CSF may trigger the ON in NMO spectrum disorders.
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收藏
页码：98 / 100
页数：3
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